Summary

Eligibility
for people ages 18-35 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UC Davis
Dates
study started
estimated completion
Principal Investigator
by Keith Baar, PhD (ucdavis)

Description

Summary

The proposed study aims to shed light on the function/importance/relevance of exercise-induced changes in exosomes to connective tissues. Exosomes are known to increase robustly in response to exercise. We have previously shown that serum isolated from subjects after they lift heavy weights increases human engineered ligament collagen content and mechanics more than serum from before they lift weight. Further, we showed that exercise-induced changes in hormones could not explain the change in ligament structure or function. These data indicate that there is a significant gap in our understanding of muscle-connective tissue crosstalk. To address this gap, the current proposal seeks to: i) isolate and sequence exosomal RNA (long non-coding, miR, and mRNA) and ii) determine whether exosomes isolated from serum after exercise increase engineered ligament mechanics and collagen content.

Keywords

Exosomes, Connective Tissue, Exercise, Resistance Exercise, Exercise trial

Eligibility

You can join if…

Open to people ages 18-35

  • Young healthy adults (18-35 y)
  • Experience with exercise (>1y)

You CAN'T join if...

  • Pregnancy
  • Smoking
  • Receiving any medication that may interfere with the study outcomes

Location

  • Hickey Laboratory accepting new patients
    Davis California 95616 United States

Lead Scientist at University of California Health

  • Keith Baar, PhD (ucdavis)
    Professor, Physiology and Membrane Biology, School of Medicine. Authored (or co-authored) 146 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
ID
NCT05616234
Study Type
Interventional
Participants
Expecting 12 study participants
Last Updated