Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UC Davis
Dates
study started
completion around
Principal Investigator
by Tokihiro Yamamoto, PhD (ucdavis)
Headshot of Tokihiro Yamamoto
Tokihiro Yamamoto

Description

Summary

The overall goal of this research study is to understand how 18F-fluorodeoxyglucose (FDG), a radioactive sugar behaves in head and neck cancer (HNC) and inflammation immediately following injection and at many hours post-injection, with the world's first total-body positron emission tomography (PET)/computed tomography (CT) scanner (EXPLORER).

Official Title

Characterizing Dynamics of FDG Uptake With Total-Body PET for Response Assessment in Radiotherapy for Head and Neck Cancer

Keywords

Head and Neck Cancer, Head and Neck Neoplasms, Total Body PET/CT Imagin, Total-body PET scan

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Stage II-IVa (American Joint Committee on Cancer, 8th edition) OC who are planned for RT (≥60 Gy) as per routine clinical standard.
  2. Patient must be ≥18 years of age.
  3. Willing and able to lay motionless in a supine position for up to 60 minutes
  4. Patient must be able to provide study specific informed consent prior to study entry.
  5. Patient must be able to adhere to the study visit schedule and other protocol requirements (including prolonged fasting).

You CAN'T join if...

  1. Prior RT for any malignancy leading to overlap with planned RT fields.
  2. Prior chemotherapy for any malignancy.
  3. Subjects suffering from severe claustrophobia.
  4. Subjects who have had a research study involving radiation within one year of enrolling in this study
  5. Subjects who are pregnant (subjects 18 to 60 years old who are able to become pregnant unless documented hysterectomy or bilateral ovarian removal is available will be tested prior to injection of imaging agent - positive test will exclude from participating in the study)
  6. Subjects who are breastfeeding
  7. Prisoners.
  8. Any significant medical condition that in the opinion of the investigator would prevent the subject from participating and/or adhering to study related procedures or interfere with subject safety (e.g., poorly controlled diabetes).
  9. Children (<18 years of age).

    10. Body weight more than 240 kg (529 pounds)

    -

Location

  • UC Davis EXPLORER Molecular Imaging Center
    Sacramento California 95816 United States

Lead Scientist at University of California Health

  • Tokihiro Yamamoto, PhD (ucdavis)
    Associate Professor, Radiation Oncology, School of Medicine. Authored (or co-authored) 46 research publications

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
ID
NCT05625217
Study Type
Interventional
Participants
Expecting 12 study participants
Last Updated