POC Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Active Intermediate, Posterior, or Pan NIU

Open to people ages 18-70

• Able and willing to provide consent
• Male and females, age 18 to 70 years
• Diagnosis of active noninfectious intermediate, posterior or panuveitis
• Must have active uveitis at Screening in at least one eye as defined by:
  1. Active inflammatory chorioretinal and/or inflammatory retinal vascular lesion or lesions, or
  2. ≥ 2+ VH in accordance with the NEI/SUN criteria
• Males and females must use highly effective methods of contraception for the entirety of the study

• Diagnosis of infectious uveitis
• Has elevated intraocular pressures or severe glaucoma
• Positive for HIV, Hepatitis B or C or active or inadequately latent tuberculosis at screening
• Positive for syphilis at screening
• Patients with QTcF >450 msec (both males and females) at screening
• Known active malignancy or history of malignancy within the past 5 years
• History of chronic drug or alcohol abuse
• Live vaccines
• No planned ocular or any other surgery during the course of the study

Other protocol-defined inclusion/exclusion criteria apply.