Acute Kidney Injury clinical trials at University of California Health
14 in progress, 8 open to eligible people
GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)
open to eligible people ages 40 years and up
The aim of this study is to evaluate the efficacy and safety of GDC-8264 compared with placebo in participants undergoing cardiac surgery who are determined to be at moderate to high risk of developing AKI and subsequent MAKE at 90 days after…
at UCLA
ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE
open to eligible people ages 18-90
The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent …
at UCSF
TIN816 in Sepsis-associated Acute Kidney Injury (SA-AKI)
open to eligible people ages 18-85
The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting with a diagnosis of…
at UCSF
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
open to eligible people ages 18 years and up
The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness. The way it does this is by…
at UCLA
Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
open to eligible people ages 18 years and up
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery.…
at UCSF
Establishment of ProNephro AKI (NGAL) Cut Off Value for Risk Assessment of Moderate to Severe Acute Kidney Injury in Adults
open to eligible people ages 22 years and up
The purpose of this research is to collect blood and urine from adult patients admitted to an intensive care unit. This is to assess the performance of the ProNephro AKI (NGAL) assay (lab test) as an aid to identify patients at risk for acute kidney …
at UC Davis
KIDney Injury in Times of COVID-19 (KIDCOV)
open to eligible people ages 18 years and up
There is an unmet need to evaluate the impact of sub-clinical/mild COVID19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable. To capture the diversity of race/ethnic risk and COVID19…
at UCSF
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
open to eligible people ages up to 22 years
QUELIMMUNE is FDA-approved under an HDE for the treatment of pediatric patients (weight ≥10kg and age ≤22 years) with AKI due to sepsis or a septic condition on antibiotic therapy and requiring RRT. The purpose of this surveillance registry is to…
at UCSF
Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury
Sorry, not yet accepting patients
This study aims to investigate, through the collection of valid scientific evidence necessary to determine safety and effectiveness, the potential use of Allogeneic Hope Biosciences Adipose-derived Mesenchymal Stem Cells (HB-adMSCs) to prevent…
at UCSF
Angiotensin 2 for AKI After OLT
Sorry, accepting new patients by invitation only
Kidney injury is a common complication following liver transplantation and is associated with a higher complication rate and increased risk of death. While there are many factors that likely contribute to kidney injury in the perioperative period, a …
at UCLA
Intraabdominal Pressure Monitoring Urinary Catheter and Kidney Perfusion Pressure
Sorry, not yet accepting patients
The goal of this clinical trial is to determine whether monitoring intra-abdominal pressure (IAP) and adjusting blood pressure accordingly to maintain optimal renal perfusion pressure can reduce the risk of acute kidney injury (AKI) after cardiac…
at UC Irvine
Liberation From Acute Dialysis
Sorry, in progress, not accepting new patients
The goal of the LIBERATE-D clinical trial is to improve outcomes for patients recovering from dialysis-requiring acute kidney injury (AKI-D). The impact of a conservative dialysis strategy compared to standard clinical practice of thrice-weekly…
at UCSF
Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - a Randomized Clinical Trial in Acute Kidney Injury
Sorry, not currently recruiting here
This randomized, controlled, pivotal study is intended to determine whether up to ten sequential 24-hour treatments with the Selective Cytopheretic Device (SCD) will improve survival in patients with Acute Kidney Injury (AKI) requiring continuous…
at UCLA
Prismocitrate 18 in Patients Receiving CRRT
Sorry, not currently recruiting here
Prismocitrate 18 is a continuous renal replacement therapy (CRRT) solution to be used as a renal replacement solution and as an anticoagulant to prevent blood clotting in the extracorporeal circuit. The delivery of CRRT therapy is provided by the…
at UCLA
Our lead scientists for Acute Kidney Injury research studies include Matthieu Legrand Joseph Cuschieri, MD Richard K. Leuchter, MD Colby B. Tanner, MD Mrinalini Sarkar, MD Shibani Pati, MD, PhD Peyman Benharash, MD, FACS Minnie Sarwal, M.D., Ph.D..
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