Relationship bw Image-deriv Features of Intraoperative ICG Visualiz of NVBs During RARP & Functional Outcome

Open to males ages 18 years and up

• 1. Subjects must be ≥18 years old, male, and sexually active.
• 1. Histologically/pathologically confirmed localized prostate adenocarcinoma.
• 1. Adequate preoperative sexual defined as a score of ≥18 on the Sexual Health Inventory for Men (SHIM) questionnaire.
• 1. Subjects who are candidates for good nerve sparing preoperatively determined by PI by assessing imaging findings.
• 1. Ability to read, write and understand and willingness to sign a written informed consent.
• 1. Subjects must pass medical clearance from primary care provider and cardiologist, if applicable.
• 1. Subject must be determined to be medical fit for RARP by Investigator.

• 1. No locally advanced or metastatic prostate adenocarcinoma.
• 1. Preoperative diagnosis of erectile dysfunction and with any history of intervention for sexual dysfunction such as intrapenile injections and intrapenile prosthesis implant.
• 1. Received neoadjuvant treatment for high-risk prostate cancer or received prior focal treatment of the prostate or prior definitive radiotherapy.
• 1. History of allergic reactions attributed to ICG.
• 1. Subjects who are preoperatively not foreseen as ideal candidates for nerve sparing interventions by PI
• 1. Subjects who are unable to comply with study and follow-up procedures as judged by the PI.
• 1. Subjects who are illiterate.
• 1. Other serious, uncontrolled concomitant diseases that may affect protocol compliance or interpretation of outcomes, including active opportunistic infections or advanced (severe) infections, or uncontrolled diabetes.
• 1. Any other disease, metabolic disorder, or abnormal finding upon physical examination or laboratory examination that makes the subject unsuitable for receiving the intervention, affects the interpretation of study outcomes, or poses risks to subject safety, as determined by the investigator.