Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UC Irvine
Dates
study started
study ends around

Description

Summary

The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.

Official Title

A Phase 1/2 Study of BMS-986482 as Monotherapy or Combination Therapy in Participants With Advanced Solid Tumors

Keywords

Advanced Solid Tumors, Immuno-oncology, Regulatory T cells, Tregs, Nivolumab, Bevacizumab, BMS-986482, Nivolumab and rHuPH20, Nivolumab/relatlimab/rHuPH20

Eligibility

You can join if…

Open to people ages 18 years and up

  • All participants must have a histologically or cytologically confirmed, advanced, unresectable/metastatic, solid malignancy measurable by RECIST v1.1, and have received, be refractory to, ineligible for, intolerant of, or refused existing therapy(ies) known to provide clinical benefit for the condition of the participant.
  • Participant must be ≥ 18 years or the legal age of consent in the jurisdiction in which the study is taking place, inclusive, at the time of signing the ICF.

You CAN'T join if...

  • History of life threatening immune mediated toxicity related to prior T-cell agonist or checkpoint inhibitor therapy, except those that are unlikely to re-occur with standard countermeasures.
  • Any significant acute or chronic medical illness which would interfere with study intervention or follow-up in the opinion of the investigator.
  • Other protocol-defined Inclusion/Exclusion criteria apply.

Locations

  • University of California, Irvine (UCI) Health - UC Irvine Medical Center accepting new patients
    Irvine 5359777 California 5332921 92612 United States
  • The Angeles Clinic and Research Institute - West Los Angeles Office accepting new patients
    Los Angeles 5368361 California 5332921 90025 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Bristol-Myers Squibb
Links
BMS Clinical Trial Information BMS Clinical Trial Patient Recruiting
ID
NCT06697197
Phase
Phase 1/2 Solid Tumor Research Study
Study Type
Interventional
Participants
Expecting 413 study participants
Last Updated