This study is not yet accepting patients

The ROAR Study: Reactive Oxygen Species and Reproduction

a study on Ovarian Aging In Vitro Fertilization Oxidative Stress

Summary

Eligibility
for people ages 18-43 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCSF
Dates
study started
completion around
Principal Investigator
by Mitchell Rosen, MD (ucsf)
Headshot of Mitchell Rosen
Mitchell Rosen

Description

Summary

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Keywords

Ovarian Aging, IVF Outcome, Oxidative Stress, Oxidative stress markers, Couples undergoing IVF

Eligibility

You can join if…

Open to people ages 18-43

  1. Female age 18-43 years
  2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
  3. Male partners 18 years of age or older.

You CAN'T join if...

  • Female partner age 44 or older
  • Planning fresh transfer (hybrid PGS cycle)
  • Cleavage stage biopsy

Location

  • University of California, San Francisco
    San Francisco California 94158 United States

Lead Scientist at University of California Health

  • Mitchell Rosen, MD (ucsf)
    Dr. Mitchell Rosen is a reproductive endocrinology and fertility expert at the UCSF Center for Reproductive Health. He also is director of the UCSF Fertillity Preservation Center, which helps patients with cancer preserve their ability to have children, despite aggressive cancer treatment.

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT06831019
Study Type
Observational
Participants
Expecting 1100 study participants
Last Updated