Colchicine to Reduce Your SympToms And Lower Levels of Inflammation, Zeroing in on Effective CPPD Disease Treatment

a study on CPPD - Calcium Pyrophosphate Deposition Disease

Summary

Eligibility
for people ages 40 years and up (full criteria)
Location
at UCLA
Dates
study started
study ends around
Principal Investigator
by John Fitzgerald, MD, PhD (ucla)
Headshot of John Fitzgerald
John Fitzgerald

Description

Summary

The goal of this clinical trial is to learn if colchicine reduces levels of proteins indicating inflammation in the blood in individuals with calcium pyrophosphate deposition (CPPD) disease. The trial will also test the effect of colchicine on joint symptoms in CPPD disease. The main questions it aims to answer are:

  • Does colchicine reduce the level of interleukin 18 (IL-18) in the blood of individuals with CPPD disease?
  • Does colchicine reduce pain scores in individuals with CPPD disease?

Researchers will compare colchicine once daily to a placebo (a look-alike pill that contains no drug) to see if colchicine works to treat CPPD disease.

Participants will:

  • Take colchicine or a placebo every day for 6 months
  • Visit the clinic 3 times in 6 months for joint examinations, surveys, and blood tests. Each visit will last 2-3 hours.
  • Speak on the telephone with researchers for about 4 times over 6 months. Each phone call will last about 5 minutes.

Official Title

A Randomized, Double-Blind, Multi-Site Placebo Controlled Trial of Colchicine in Calcium Pyrophosphate Deposition Disease

Keywords

CPPD - Calcium Pyrophosphate Deposition Disease, colchicine, CPPD disease, calcium pyrophosphate, pseudogout, Chondrocalcinosis, Colchicine Pill

Eligibility

You can join if…

Open to people ages 40 years and up

  • Provide written informed consent
  • Fulfill ACR/EULAR 2023 CPPD classification criteria
  • Acute or chronic joint inflammation currently or in the past 3 months, not attributable to another condition (Joint Inflammation defined as: At least 1 joint this is swollen, red, or warm to the touch; with or without corresponding tenderness)
  • Pain visual analog scale (pain VAS) >=30 at screening

You CAN'T join if...

  • Age <40 years
  • Chronic diarrhea
  • Gout, rheumatoid arthritis, psoriatic arthritis, or cirrhosis
  • Ongoing use of colchicine and unwilling to undergo a 30-day wash-out period (note: patients using colchicine at screening can enroll if they agree to a 30-day wash-out before randomization)
  • Pregnant or breast-feeding
  • Use of methotrexate, hydroxychloroquine, tocilizumab or canakinumab in the past 4 weeks
  • Use of anakinra, oral glucocorticoid, or intra-articular steroid in the past 1 week
  • Ongoing use of strong CYP3A4 inhibitors per FDA package insert for colchicine
  • Ongoing use of P-glycoprotein inhibitors per FDA package insert for colchicine
  • Known allergy to colchicine
  • Planned joint surgery in the next 6 months
  • CPPD clinical presentation isolated to Crowned Dens Syndrome with no additional peripheral joint involvement
  • Screening labs with any of the following:
    1. Hemoglobin < 9 g/dL
    2. WBC <3 x 109/L
    3. Platelets <110 x109/L
    4. Creatinine clearance (CrCl) <30 mL/min
    5. ALT or AST >3x upper limit of normal (ULN)
  • Patient is considered by investigator to be an unsuitable candidate for the study for any reason

Locations

  • University of California - Los Angeles accepting new patients
    Los Angeles California 90095 United States
  • Medical College of Wisconsin accepting new patients
    Milwaukee Wisconsin 53226 United States

Lead Scientist at University of California Health

  • John Fitzgerald, MD, PhD (ucla)
    Professor of Clinical, Medicine. Authored (or co-authored) 85 research publications. Research interests: Gout · CPPD · Ultrasound · Synovial fluid · Knee Replacement · Health Disparities

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Brigham and Women's Hospital
ID
NCT06855433
Phase
Phase 2 CPPD - Calcium Pyrophosphate Deposition Disease Research Study
Study Type
Interventional
Participants
Expecting 150 study participants
Last Updated
Contact us about this trial