Chronic Infections and Inflammation in ME/CFS: An Observational Study

a study on Chronic Fatigue Syndrome

Summary

Eligibility
for people ages 18 years and up (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCSF
Dates
study started
study ends around
Principal Investigator
by Michael J. Peluso (ucsf)
Headshot of Michael J. Peluso
Michael J. Peluso

Description

Summary

CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled. Volunteers will be observed and sampled over time to identify the long-terms biological drivers and impact of their condition. The overall goal is to understand the biological and physiological mechanisms that are driving this condition.

Details

CHIIME is an observational, prospective study of individuals who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The overall objective of the study is to investigate the clinical characteristics and biological signatures of ME/CFS over time by performing deep clinical phenotyping with high-quality biospecimen collection and curation of individuals with and without the condition.

Enrolled volunteers will be seen at San Francisco General Hospital. Visits include a detailed interview, biospecimen collection, and various assessments. No personal identifiers are used for specimen bank samples.

Keywords

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, ME/CFS, myalgic encephalomyelitis, chronic fatigue syndrome, Post-COVID ME/CFS

Eligibility

You can join if…

Open to people ages 18 years and up

  • Willing and able to provide written informed consent
  • At least 18 years of age
  • Either: (1) a reported diagnosis of ME/CFS or (2) no history of ME/CFS or other infection-associated chronic conditions (healthy control)

You CAN'T join if...

  • Self reported or documented chronic anemia with hemoglobin <9 g/dL
  • Known HIV, hepatitis B, or hepatitis C infection
  • Diagnosis of an infection-associated chronic condition other than ME/CFS or Long COVID (e.g. chronic Lyme disease, post-Ebola syndrome, etc.)
  • Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent
  • Active drug or alcohol use or dependence that, in the opinion of the PI, would interfere with adherence to study requirements or to give informed consent

Location

  • Zuckerberg San Francisco General Hospital accepting new patients
    San Francisco 5391959 California 5332921 94110 United States

Lead Scientist at University of California Health

  • Michael J. Peluso (ucsf)
    I am an infectious disease clinician and researcher. My primary interests are HIV cure and Long COVID. For HIV, I am involved with clinical and laboratory research aimed at understanding the HIV reservoir and implementing clinical trials to disrupt the reservoir with the aim of inducing antiretroviral therapy-free HIV remission.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT07227441
Study Type
Observational
Participants
Expecting 200 study participants
Last Updated