Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCSD
Dates
study started
study ends around
Principal Investigator
by Monica Guma, MD, PhD (ucsd)
Headshot of Monica Guma
Monica Guma

Description

Summary

To study the effect of anti-inflammatory diet on clinical and biological outcomes in lupus

Details

The investigators aim to evaluate how inflammation changes in individuals with lupus and to identify molecules and gut bacteria that may help predict disease flares. Blood and stool samples will be analyzed in the laboratory and compared with samples collected from the same participants following dietary changes.

This is an exploratory study designed to generate preliminary data on the short-term effects of dietary changes and treatment on blood biomarkers and the gut microbiome. The findings may provide insights into the mechanisms underlying lupus and could ultimately contribute to the development of new therapeutic approaches.

Keywords

Systemic Lupus Erthematosus (SLE), lupus, diet, anti-inflammatory diet, mediterranean diet, cellcept, mycophenalate, microbiome

Eligibility

You can join if…

Open to people ages 18 years and up

  • patients who meet the 2019 EULAR/ACR Classification Criteria for SLE
  • patients who are on Cellcept or Myfortic for at least 3 months prior to screening
  • patients with a score of ≥55 on the Patient Reported Outcomes Measurement Information System (PROMIS) Pain interference scale.

You CAN'T join if...

  • pregnant or lactating patients,
  • patients with food allergy
  • patients on antibiotics within 4 weeks of the screening
  • patients that change the SLE therapy during the length of the study (12 weeks).

Location

  • Altman Clinical Translational Research Insitute (UC San Diego) accepting new patients
    La Jolla California 92097 United States

Lead Scientist at University of California Health

  • Monica Guma, MD, PhD (ucsd)
    Professor, Medicine, Vc-health Sciences-schools. Authored (or co-authored) 100 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT07713940
Study Type
Interventional
Participants
Expecting 36 study participants
Last Updated