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Cognitive Decline clinical trials at UC Health
6 in progress, 2 open to new patients

  • Exercise in Adults With Mild Memory Problems

    open to eligible people ages 65-89

    This study evaluates the effects of physical exercise on cognition, functional status, brain atrophy and blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment. Half of participants will participate in a stretching-balance-range of motion exercise program, while the other half will participate in a moderate/high aerobic training program.

    at UC Irvine

  • Remote Preconditioning Over Time To Empower Cerebral Tissue

    open to eligible people ages 40 years and up

    Previous studies in animals and humans has shown that brief periods of reduced blood flow to one organ or tissue in the body can help protect other tissues from subsequent injury caused by reduced blood flow such as a stroke. This phenomenon is known as remote ischemic preconditioning and may help protect brain cells after a stroke. The investigators are studying a specific stroke type called subcortical stroke that is very common and has a high rate of recurrent stroke and cognition problems despite intensive prevention measures.

    at UCLA

  • A Study of High-dose Vitamin D Supplements in Older Adults

    “This studywill test if supplementing high dose vitamin D will correct severely low vitamin D levels in adults 65-90 years old.”

    Sorry, not yet accepting patients

    This Phase II randomized clinical trial aims to test if supplementation with high dose oral vitamin D will successfully correct vitamin D insufficiency, compared to treatment with standard (RDA) dose vitamin D in a diverse community-based elderly cohort. The effect of high-dose vs. standard-dose vitamin D on altering cognitive trajectories will also be assessed and data will be expected to be used in designing a potential definitive Phase III trial in elderly groups at risk for dementia. A total of 180 elderly persons with longitudinal biomarkers, neuropsychological testing and brain MRI scans will be enrolled, with 152 (~50 with MCI, 50 with mild AD and 50 with no cognitive impairment) expected to complete the 3½-year study. One-half of each diagnostic group will be randomized to treatment with high-dose vitamin D3 (4,000 IU daily) or to standard dose Vitamin D (600 IU capsule daily + ~200 IU dietary = ~800 IU total/day). Longitudinal MRI analyses will provide an estimate of the treatment effect size on brain atrophy rate. Vitamin D receptor genotype polymorphisms and their impact on response to oral supplementation will also be examined. If vitamin D supplementation improves cognitive outcome, this could have a large impact on the public health, since low vitamin D status is a common, readably treatable condition which may provide a novel window to prevent dementia and AD. Furthermore, the higher prevalence of AD and dementia in African Americans and Latinos could be partially attributable to vitamin D insufficiency.

    at UC Davis

  • Body-Brain Training MS Cognition

    Sorry, not yet accepting patients

    Adaptive Body-Brain Training for Patients with Cognitive Deficits due to Multiple Sclerosis: a pilot study WHO: 36 participants with a confirmed diagnosis of Multiple Sclerosis (MS) or Clinically Isolated Syndrome (CIS) able to engage in moderate physical activity. WHY: The purpose of this study is to test whether a computerized cognitive training tool with/or without a physical exercise program can help improve cognitive functions, such as memory and thinking, for patients with MS. WHAT: Complete a set of tests (physical and cognitive) at baseline, where a Fitbit Flex device at home for the duration of the study, 3 supervised sessions for 4 weeks at UCSF, one final follow up visit for physical and cognitive tests 6 months after the final supervised session. WHERE: UCSF Weill Institute for Neurosciences (675 Nelson Rising Lane, San Francisco, CA)

    at UCSF

  • Digital Cognition in Multiple Sclerosis

    Sorry, in progress, not accepting new patients

    A DIGITAL THERAPEUTIC TO IMPROVE THINKING IN MULTIPLE SCLEROSIS WHO: 65 participants with a confirmed diagnosis of Multiple Sclerosis (MS) WHY: Purpose of the study is to compare the effect of 2 tablet-based brain training digital tools on important components of thinking (cognition). WHAT: Complete a set of tests (physical and cognitive) at baseline, 6 weeks and 14 weeks, and use one of two brain training tools on an iPad in your home, for 25 minutes a day, 5 days a week, for 6 weeks. WHERE: UCSF WEILL INSTITUTE FOR NEUROSCIENCES (675 Nelson Rising Lane, San Francisco, CA)

    at UCSF

  • Extension Study of Intrathecal Enzyme Replacement for Cognitive Decline in MPS I

    Sorry, accepting new patients by invitation only

    This is a five-year extension study of the pilot study, "Intrathecal Enzyme Replacement for Cognitive Decline in MPS I". Participants must have completed the pilot study to participate in this study.

    at UCSF UCLA

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