Contraception clinical trials at University of California Health
17 in progress, 6 open to eligible people
A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
open to eligible females ages 18-40
This is a Phase I multicenter, open-label, dose-ranging, three-dose PK and PD study of injectable LB administered as an IM or SQ injection at 40 mg, and subsequently at 50mg SQ and then 60 mg SQ depending on the preliminary pharmacokinetic and pharmacodynamic results obtained with 40 mg dosing.
at UC Davis
Injectable DMAU for Male Contraception in Healthy Male Volunteers (CCN015)
open to eligible males ages 18-50
This is a Phase I multicenter, double-blind, single dose, dose-ranging study, in healthy men to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics of Dimethandrolone Undecanoate (DMAU) administered as an intramuscular or subcutaneous injection.
at UCLA
Patient-Centered Reproductive Decision Support Tool for Women Veterans
open to eligible females ages 18-44
The investigators have developed a web-based decision support tool to help women Veterans get the information and care they need to achieve their reproductive goals, whether that includes optimizing their health before desired pregnancies or birth control to avoid unwanted pregnancies. The study will test the effect of sending a weblink to the decision tool to women Veterans prior to primary care visits at the VA. Half of participants will be sent a weblink before their appointment, and half will not be sent the link. The investigators hypothesize that participants who are sent the link will be more likely to report patient-centered discussions of their reproductive needs at visits, feel confident in communicating with their health care providers, have accurate knowledge about reproductive health, and choose birth control methods that best fit their preferences and needs.
at UCSD UCSF
Taking a birth control pill or planning to? Willing to use a birth control implant too?
“Join a study that aims to improve how well your birth control works at preventing pregnancy!”
open to eligible females ages 18 years and up
Women currently using or starting a combined oral contraceptive (COC) will be offered study enrollment. Study subjects will have a Nexplanon placed and followed for approximately 12 months to evaluate if they continue the implant, the COC, or both, and to assess bleeding patterns and adverse events.
at UC Davis
UCSF College Health Study on Contraceptive Training and Education at Community Colleges
open to eligible females ages 18-25
The purpose of this study is to measure whether a training and education intervention for clinic staff and young women aged 18-25 on contraceptive methods, including intrauterine devices (IUDs) and the implant, will result in greater contraceptive knowledge and access among students in community colleges.
at UCSF
Keep Contraceptive Arm Long Acting-iMplant (CALM) and Carry On
open to eligible females ages 18-50
The investigators will conduct an observational study comparing the number of bleeding days before and after contraceptive implant (Nexplanon) replacement.
at UCSD
"My Decision" Tubal Sterilization Decision Support Tool
Sorry, in progress, not accepting new patients
This study seeks to test a web-based decision support tool developed to enhance low-income women's ability to make informed decisions about tubal sterilization that align with their preferences, values and reproductive goals. Half of participants will receive usual care, while the other half will use the web-based decision aid plus usual care. The investigators hypothesize that compared to women who receive usual care alone, women randomized to the decision aid arm will have greater knowledge about sterilization and alternative options, lower decisional conflict, and will be more satisfied with their contraceptive decision at 3-month follow-up.
at UCSF
Compare Two Copper IUDs: Mona Lisa NT Cu380 Mini and ParaGard
Sorry, in progress, not accepting new patients
This will be a multi-site, participant-blinded, randomized clinical trial. The investigators will randomize 1000 eligible participants in a 4:1 ratio to two different copper IUDs: 800 to Mona Lisa NT Cu380 Mini and 200 to ParaGard.
at UC Davis UCSF
Evaluation of the Efficacy, Safety, and Tolerability of LevoCept
Sorry, not yet accepting patients
To assess the contraceptive efficacy (prevention of pregnancy) of LevoCept
at UC Davis
Intervening on Women's Health for Rural Young Breast Cancer Survivors
Sorry, not currently recruiting here
The purpose of this study is to evaluate the effectiveness of a multi-component intervention to improve young breast cancer survivors' engagement in goal-concordant oncofertility care, concurrently with observing and gathering information on how the intervention is implemented. The investigators hypothesize that implementation of the intervention will result in increased young breast cancer survivors' engagement in goal-concordant oncofertility care.
at UCSD
IUD Placement Without Sounding
Sorry, not yet accepting patients
The purpose of this study is to determine the feasibility of a uterine sound sparing technique for levonorgestrel 52 mg intrauterine device (IUD) placement. This study will be conducted in three phases. In phase one, the IUD will be placed in standard fashion with a uterine sound to obtain baseline data. Phase two and three are interventional phases that will investigate IUD placement without the use of a uterine sound. In phase two, the IUD will be placed without the use of a uterine sound, but under abdominal ultrasound guidance. In phase three, the IUD will be placed without the use of a uterine sound and without ultrasound guidance. An ultrasound exam will be completed at the end of phase two and three to determine if the IUD was successful placed. To answer the secondary objectives, for all study phases the investigators will measure the procedure time, the participant-reported maximum pain during and 5-minutes post placement and the provider assessment of ease of placement. To determine the exploratory objective of IUD expulsion and perforation rate for a uterine sound sparing IUD placement technique, participants in phases two and three will complete a 30-day phone follow up and 90-day in clinic follow up to evaluate for IUD expulsion or perforation. The investigators hypothesize that the levonorgestrel 52 mg IUD can successfully be inserted without uterine sounding.
at UC Davis
Join a study to confirm if the Nexplanon implant remains highly effective for up to 5 years
“We're looking for women who have been using Nexplanon for 2-1/2 to 3 years and want to continuing using the implant for a total of 5 years”
Sorry, in progress, not accepting new patients
The primary purpose of this study is to assess the efficacy and safety of the etonogestrel (ENG) contraceptive implant during participants' fourth and fifth years of use when used as the only method of contraception. The ENG implant is currently approved for a 3-year duration, and this study aims to confirm available evidence suggesting that the ENG implant remains highly effective when used up to 5 years.
at UC Davis UCLA
Postpartum Integration of Vaccines and Contraception Trial
Sorry, not yet accepting patients
This study aims to examine how to implement a gender-transformative post-partum family planning program integrated into community-based infant vaccination services, and to evaluate preliminary effectiveness of this approach on postpartum contraceptive use in a low resource, rural setting.
at UCSD
Study of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception
Sorry, in progress, not accepting new patients
The long term objective is to develop a gel to be used as a male contraceptive.
at UC Davis UCLA
Study of the Safety and Efficacy of Ulipristal Acetate (UPA) Used Daily as a Contraceptive
Sorry, currently not accepting new patients, but might later
This is a Phase IIb multicenter, open-label, non-comparative trial of continuous daily oral 10 mg of ulipristal acetate (UPA) to evaluate its contraceptive efficacy as the primary method of contraception.
at UC Davis UCSF
Tipping Point: Using Social Network Theory to Accelerate Scale and Impact
Sorry, in progress, not accepting new patients
This study will assess the nature and impact of social norms and networks to promote FP (Family Planning) intervention effects among low parity, married adolescent and young women in the Maradi region of Niger. Research activities will be layered on top of the USAID-funded Kulawa FP program that seeks to change FP-related behaviors among young, low parity women at scale in Niger in a subset of implementing villages. Kulawa, implemented by Save the Children U.S. (SCUS) and funded by USAID (2020-2025), will include small-group discussion for young, low parity girls coupled with community dialogues to address individual, social, and health system constraints to FP use and influence social norms that govern FP use. UCSD will not provide any services or implement any interventions as part of this study.
at UCSD
Assessment of Contraceptive Safety and Effectiveness in Cystic Fibrosis
Sorry, in progress, not accepting new patients
The long-term goal is to study the safety and effectiveness of hormonal contraception for women with cystic fibrosis (CF) and contribute to national guidelines that the Cystic Fibrosis Foundation and the Centers for Disease Control and Prevention (CDC) provide to clinicians. The study objectives are to determine whether hormonal contraceptive methods improve overall pulmonary health, worsen CF-related disease or CF liver disease, or are effective against unwanted pregnancy with concomitant CF transmembrane conductance regulator (CFTR) modulator use. The hypothesis is that hormonal contraceptive methods are safe and do not worsen CF-related complications over time,improve FEV-1 when compared to non-hormonal users, and oral birth control methods with CFTR modulator use.
at UCSD
Our lead scientists for Contraception research studies include Sarah Averbach, MD, MAS Melissa C Matulich, MD MAS Jay G. Silverman, PhD Cynthia C. Harper, PhD Sheila Mody, MD, MPH Christina Wang, MD Mitchell Creinin, MD.
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