Cystic Fibrosis clinical trials at University of California Health
16 in progress, 6 open to eligible people
4D-710 in Adult Patients With Cystic Fibrosis
open to eligible people ages 18 years and up
This is a Phase 1/2 multicenter, open-label, single dose trial of 4D-710 investigational gene therapy in adults with cystic fibrosis.
at UCSF
Exercise in Child Health
open to eligible people ages 10-17
This study is a cooperative investigation funded by the NIH. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) UCI (lead site with its affiliate CHOC), 2) Northwestern University (with its affiliate…
at UC Irvine
Lung Transplant READY CF 2: A Multi-site RCT
open to eligible people ages 18 years and up
Lung transplant is an option for treating end-stage lung disease in cystic fibrosis (CF). In the United States, more people with CF and low lung function die each year than undergo lung transplant. More than half of people with CF who die without a…
at UCLA
Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
open to eligible people ages 6 years and up
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of…
at UC Davis UCSD
Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators
open to eligible people ages 12 years and up
The REACH study is for people with CF who do not take cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The goal of the REACH study is to collect research data, including health data and specimens, from people with CF who do not …
at UCSD UCSF
Sinus Surgery on Individuals With Cystic Fibrosis
open to eligible people ages 18-99
This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be…
at UCLA
RCT2100 in Healthy Participants and in Participants With CF
Sorry, not currently recruiting here
This is the first-in-human study with RCT2100 and is designed to provide safety and tolerability data for future clinical studies.
at UCSD
Long-term Safety and Efficacy of VX-121 Combination Therapy
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate the long-term safety, tolerability, and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in participants with cystic fibrosis.
at UC Davis UCSF
Streamlined Treatment of Pulmonary Exacerbations in Pediatrics
Sorry, not currently recruiting here
The STOP PEDS RCT is a multicenter, parallel, open label randomized controlled trial evaluating the long-term (one year) and short-term safety and efficacy of two antibiotic treatment strategies for the management of outpatient pulmonary…
at UCSD
Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Airway Infection
Sorry, not accepting new patients
The primary objective of this program is to provide expanded access to aztreonam lysine for inhalation (AZLI) 75 mg prior to its commercial availability to patients with cystic fibrosis (CF) and chronic P. aeruginosa airway infection who have…
at UCSF
CHaractErizing CFTR Modulated Changes in Sweat Chloride and Their Association With Clinical Outcomes
Sorry, in progress, not accepting new patients
This is a multicenter, cross-sectional, cohort study which will collect contemporary sweat chloride (SC) values from approximately 5000 Cystic Fibrosis (CF) patients prescribed and currently receiving commercially approved Cystic Fibrosis…
at UCSD
Colorectal Cancer Screening in Cystic Fibrosis
Sorry, in progress, not accepting new patients
This multi-center study will compare multi-target DNA and quantitative FIT stool-based testing to colonoscopy in individuals with Cystic Fibrosis (CF) undergoing colon cancer screening with colonoscopy. The primary endpoint is detection of any…
at UCLA
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
Sorry, accepting new patients by invitation only
The objective of this registry is to collect and evaluate various clinical effectiveness parameters in patients with transplanted donor lung that were preserved and transported within the LUNGguard system, as well as retrospective standard of care…
at UCSF
PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis
Sorry, accepting new patients by invitation only
Isolation of nontuberculous mycobacteria (NTM) from the sputum of individuals with CF is an increasingly common finding, and the lack of an evidenced-based approach to treatment of NTM disease has been identified as one of the greatest unmet needs…
at UCSD
PREDICT Trial: PRospective Evaluation of NTM Disease In CysTic Fibrosis
Sorry, accepting new patients by invitation only
Isolation of nontuberculous mycobacteria (NTM) from the sputum of individuals with CF is an increasingly common finding, and the lack of an evidenced-based approach to the diagnosis of NTM disease has been identified as one of the greatest unmet…
at UCSD
Pregnancy in Women with Cystic Fibrosis
Sorry, in progress, not accepting new patients
In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane conductance regulator…
at UCSD
Our lead scientists for Cystic Fibrosis research studies include Jonathan Singer, MD Grant Turner, MD, MHA, FACP Daniel M. Beswick, MD Dan Cooper Kathryn Akong, MD.
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