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Cystic Fibrosis clinical trials at University of California Health

16 in progress, 6 open to eligible people

Showing trials for
  • 4D-710 in Adult Patients With Cystic Fibrosis

    open to eligible people ages 18 years and up

    This is a Phase 1/2 multicenter, open-label, single dose trial of 4D-710 investigational gene therapy in adults with cystic fibrosis.

    at UCSF

  • Exercise in Child Health

    open to eligible people ages 10-17

    This study is a cooperative investigation funded by the NIH. The project is a collaboration among three major NIH Clinical Translational Science Awardees: 1) UCI (lead site with its affiliate CHOC), 2) Northwestern University (with its affiliate…

    at UC Irvine

  • Lung Transplant READY CF 2: A Multi-site RCT

    open to eligible people ages 18 years and up

    Lung transplant is an option for treating end-stage lung disease in cystic fibrosis (CF). In the United States, more people with CF and low lung function die each year than undergo lung transplant. More than half of people with CF who die without a…

    at UCLA

  • Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

    open to eligible people ages 6 years and up

    The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of…

    at UC Davis UCSD

  • Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

    open to eligible people ages 12 years and up

    The REACH study is for people with CF who do not take cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The goal of the REACH study is to collect research data, including health data and specimens, from people with CF who do not …

    at UCSD UCSF

  • Sinus Surgery on Individuals With Cystic Fibrosis

    open to eligible people ages 18-99

    This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be…

    at UCLA

  • RCT2100 in Healthy Participants and in Participants With CF

    Sorry, not currently recruiting here

    This is the first-in-human study with RCT2100 and is designed to provide safety and tolerability data for future clinical studies.

    at UCSD

  • Long-term Safety and Efficacy of VX-121 Combination Therapy

    Sorry, in progress, not accepting new patients

    The purpose of this study is to evaluate the long-term safety, tolerability, and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in participants with cystic fibrosis.

    at UC Davis UCSF

  • Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

    Sorry, not currently recruiting here

    The STOP PEDS RCT is a multicenter, parallel, open label randomized controlled trial evaluating the long-term (one year) and short-term safety and efficacy of two antibiotic treatment strategies for the management of outpatient pulmonary…

    at UCSD

  • Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Airway Infection

    Sorry, not accepting new patients

    The primary objective of this program is to provide expanded access to aztreonam lysine for inhalation (AZLI) 75 mg prior to its commercial availability to patients with cystic fibrosis (CF) and chronic P. aeruginosa airway infection who have…

    at UCSF

  • CHaractErizing CFTR Modulated Changes in Sweat Chloride and Their Association With Clinical Outcomes

    Sorry, in progress, not accepting new patients

    This is a multicenter, cross-sectional, cohort study which will collect contemporary sweat chloride (SC) values from approximately 5000 Cystic Fibrosis (CF) patients prescribed and currently receiving commercially approved Cystic Fibrosis…

    at UCSD

  • Colorectal Cancer Screening in Cystic Fibrosis

    Sorry, in progress, not accepting new patients

    This multi-center study will compare multi-target DNA and quantitative FIT stool-based testing to colonoscopy in individuals with Cystic Fibrosis (CF) undergoing colon cancer screening with colonoscopy. The primary endpoint is detection of any…

    at UCLA

  • Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs

    Sorry, accepting new patients by invitation only

    The objective of this registry is to collect and evaluate various clinical effectiveness parameters in patients with transplanted donor lung that were preserved and transported within the LUNGguard system, as well as retrospective standard of care…

    at UCSF

  • PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis

    Sorry, accepting new patients by invitation only

    Isolation of nontuberculous mycobacteria (NTM) from the sputum of individuals with CF is an increasingly common finding, and the lack of an evidenced-based approach to treatment of NTM disease has been identified as one of the greatest unmet needs…

    at UCSD

  • PREDICT Trial: PRospective Evaluation of NTM Disease In CysTic Fibrosis

    Sorry, accepting new patients by invitation only

    Isolation of nontuberculous mycobacteria (NTM) from the sputum of individuals with CF is an increasingly common finding, and the lack of an evidenced-based approach to the diagnosis of NTM disease has been identified as one of the greatest unmet…

    at UCSD

  • Pregnancy in Women with Cystic Fibrosis

    Sorry, in progress, not accepting new patients

    In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane conductance regulator…

    at UCSD

Our lead scientists for Cystic Fibrosis research studies include .

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