Degenerative Disc Disease clinical trials at University of California Health

7 in progress, 4 open to eligible people

Showing trials for

  • Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain

    open to eligible people ages 18 years and up

    The primary purpose of this study is to evaluate the efficacy of rexlemestrocel-L+HA compared to control in reducing low back pain at 12 months post-treatment and safety of a single injection of rexlemestrocel-L+HA injected into a lumbar intervertebral disc compared to control through 12 months post-treatment.

    at UC Davis UCSF

  • Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

    open to eligible people ages 22-69

    The study is a prospective, multi-center cohort study of patients with two-level DDD implanted with CDA adjacent to ACDF (hybrid construct). The overall success of the hybrid procedure will be compared to 2-level ACDF historical controls from the Mobi-C IDE trial. 97 patients will receive the hybrid surgery and will be followed for a minimum of 2 years.

    at UC Davis

  • DEXA-C Anterior Cervical Interbody System

    open to eligible people ages 18 years and up

    FDA Cleared interbody product for the cervical spine, designed to match a patients DEXA scan for increase in fusion rate.

    at UC Irvine

  • Artificial Disc Implants in Cervical Disc Arthroplasty

    open to eligible people ages 18-60

    This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nuvasive Simplify implementing a three-piece design with two endplates and a semi-constrained mobile core while the Biomet Zimmer Mobi-C implements an unconstrained three piece design. Subjects will be age-matched and randomly assigned to either implant with informed consent. All subjects will undergo a variety of assessments that evaluate neck disability, quality of life, pain, physiological outcome (radiographic assessments), and neck range-of motion before and after their procedure. One baseline testing will be conducted along with three post-operation visits (three months, six months, and one year) in accordance to standard follow-up procedure. Thus, the duration of participation in the study will be approximately one and a half years.

    at UCLA

  • P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation

    “Please consider joining this clinical research study examining the effectiveness of an investigational device.”

    Sorry, in progress, not accepting new patients

    The aim of this trial is to evaluate if P-15L bone graft (investigational device) is not inferior in effectiveness and safety to local autologous bone (and allograft where necessary) as an extender (control device) when applied in instrumented transforaminal lumbar interbody fusion (TLIF) in subjects with degenerative disc disease (DDD). In addition to the general overall objective, a sub-group analysis will be performed on the high-risk subject population (tobacco use, obesity, diabetes), as previous studies have shown negative effects of smoking, obesity and diabetes on fusion and bone healing, increased peri/postoperative complications, and lower patient-reported outcome scores.

    at UC Davis UC Irvine

  • Lumbar Interbody Implant Study

    Sorry, accepting new patients by invitation only

    The objective of this study is to evaluate the safety and performance of NuVasive interbody implants when used during thoracic and/or lumbar spine surgery as measured by reported complications, radiographic outcomes, and patient-reported outcomes. This study is being undertaken to identify possible residual risks and to clarify mid- to long-term clinical performance that may affect the benefit/risk ratios of these interbody implants.

    at UCSD

  • Posterior Cervical Fixation Study

    Sorry, accepting new patients by invitation only

    The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported outcomes (PROs).This study is being undertaken to identify possible residual risks and to clarify mid-to long-term clinical performance that may affect the benefit/risk ratio of posterior fixation systems.

    at UC Irvine

Our lead scientists for Degenerative Disc Disease research studies include .

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