Dementia clinical trials at University of California Health
49 in progress, 20 open to eligible people
Deep Repetitive Transcranial Magnetic Stimulation (rTMS) of the Precuneus for Alzheimer Disease (AD)
open to eligible people ages 60-100
The goal of this clinical trial is to learn if using deep repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus is feasible, tolerable, and potentially efficacious for memory in Probable Alzheimer's Dementia. Previous work…
at UCLA
Dementia and Diabetes Prevention Program
open to eligible people ages 60 years and up
This is a multicenter, randomized 2-arm clinical trial of two lifestyle interventions varying in intensity and format, in 400 older African American and non-Hispanic whites at increased risk of cognitive decline and dementia in the East San…
at UC Davis
Dementia Family Caregiver Study
open to eligible people ages 18 years and up
The proposed study will test a 3-month, community health worker (CHW) delivered home visit, culturally and language-appropriate intervention for ethnic and underserved dementia family caregivers of persons with dementia (PWD) using wearable…
at UC Irvine
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001
open to eligible people ages 18-80
The purpose of this study is to assess the safety, tolerability, biomarker, cognitive and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug…
at UCSD
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
open to eligible people ages 40-75
This is a first in human study that will assess the safety and diagnostic performance of [18F]RP-115 (fluorine-18 labeled RP115), a positron emission tomography (PET) agent. This agent has the potential to identify the early changes that occur in…
at UCSF
Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type
open to eligible people ages 50-90
This study will be conducted to evaluate the efficacy, safety, tolerability, and pharmacokinetics of masupirdine compared to placebo for the treatment of agitation in participants with dementia of the Alzheimer's type.
at UCLA
Music, Social Attention, and Dementia
open to eligible people ages 55-89
This is an exploratory mixed-methods control-treatment study to evaluate if participation in rhythmic musical activities improves social attention and connectedness in individuals living with mild to moderate bvFTD and AD, and their caregivers.…
at UCSF
Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
open to eligible people ages 18 years and up
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role. These caregivers express a desire for education and support. …
at UCSF
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
open to eligible people ages 55 years and up
As our population ages, more older adults face motor-cognitive declines, increasing their risk of falls and fear of falling. Exercise is an effective way to maintain cognitive function, as supported by recent studies. However, those with poor motor…
at UCLA
TabCAT Brain Health Assessment in Primary Care
open to eligible people ages 18 years and up
Efficient and user-friendly paradigms to detect cognitive impairment, including dementia are needed in primary care. The TabCAT Brain Health Assessment accurately detects cognitive impairment via an appealing tablet interface with automated scoring…
at UCSF
Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
open to eligible people ages 55-89
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination …
at UCSF
Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
open to eligible people ages 18-85
The purpose of the study is to test the safety and tolerability of twice daily Verdiperstat in patients with semantic variant primary progressive aphasia (svPPA) due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP).…
at UCSF
Alzheimer's Disease Neuroimaging Initiative 4
open to eligible people ages 55-90
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study has been to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2,…
at UC Davis UC Irvine UCLA UCSD UCSF
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
open to eligible people ages 18 years and up
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium…
at UCLA UCSD UCSF
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
open to eligible people ages 18 years and up
This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 575 participants will be enrolled and can expect to be on study for up to 5 years.
at UCLA UCSF
Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
open to eligible people ages 18 years and up
The investigators are researching families with inherited inclusion body myopathy (IBM) and/or Paget disease of bone (PDB) and/or dementia (FTD) which is also called IBMPFD. IBMPFD is caused by mutations in the VCP gene. Our main goal is to…
at UC Irvine
Clinical Procedures to Support Research in ALS
open to eligible people ages 18 years and up
The purpose of the Clinical Procedures To Support Research (CAPTURE) study is to utilize information collected in the medical record to learn more about a disease called amyotrophic lateral sclerosis (ALS) and related disorders.
at UC Irvine
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
open to eligible people ages 18 years and up
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients …
at UCLA UCSD
North American Prodromal Synucleinopathy Consortium Stage 2
open to eligible people ages 18 years and up
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
at UCLA
Trial-Ready Cohort-Down Syndrome (TRC-DS)
open to eligible people ages 25-55
The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 450 participants in total including co-enrolled in the…
at UC Irvine
AL001 in Frontotemporal Dementia (INFRONT-3)
Sorry, in progress, not accepting new patients
A phase 3 double blind, placebo controlled study evaluating the efficacy and safety of AL001 in participants at risk for or with frontotemporal dementia due to heterozygous mutations in the progranulin gene.
at UCSD
Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
Sorry, not currently recruiting here
The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individuals with AD-causing mutations. This study will…
at UCSD
JNJ-63733657 in Participants With Early Alzheimer's Disease
Sorry, in progress, not accepting new patients
The primary purpose of this study is to evaluate the effect of JNJ-63733657 versus placebo on clinical decline as measured by the Integrated Alzheimer's Disease Rating Scale (iADRS), a composite of cognition and function.
at UCLA UCSD
Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
Sorry, not currently recruiting here
The purpose is to evaluate the biomarker effect, safety, and tolerability of investigational study drugs in participants who are known to have an Alzheimer's disease (AD)-causing mutation. Stage 1 will determine if treatment with the study drug…
at UCSD
Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age
Sorry, in progress, not accepting new patients
In this study, researchers will learn more about a study drug called BIIB080. The study will focus on participants with mild cognitive impairment or mild dementia due to AD. The main question researchers are trying to answer is if BIIB080 can slow…
at UCLA UCSD UCSF
Brain Health Project for Korean American Dementia Caregivers
Sorry, not yet accepting patients
The caregivers of persons with dementia face significant emotional, physical, and financial challenges, particularly among under-resourced communities like Korean Americans, who encounter unique obstacles, including language barriers and limited…
at UCSF
Caregivers Preparing for Their Own Health Care Emergency
Sorry, not yet accepting patients
The proposed research will develop and test an online Emergency Preparedness Toolkit to help caregivers prepare for their own unexpected health events. Caregivers of persons with dementia often ignore their own health needs as their primary focus is …
at UC Davis
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
Sorry, in progress, not accepting new patients
To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related…
at UCSD
Escitalopram for Agitation in Alzheimer's Disease
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate the safety and efficacy of escitalopram for agitation in Alzheimer's dementia.
at UCLA
Intranasal Oxytocin for Frontotemporal Dementia
Sorry, in progress, not accepting new patients
The purpose of this study is to assess the safety, tolerability and effects on behaviour of Syntocinon given intranasally (by a spray into the nostrils) compared to placebo (an inactive saline substance that contains no medication) in participants…
at UCLA UCSF
Metformin in Alzheimer's Dementia Prevention
Sorry, in progress, not accepting new patients
MAP will be a multisite phase II/III 1:1 randomized controlled trial (RCT) of long acting metformin (reduced mass Glucophage XR) vs. matching placebo in 326 men and women with early and late aMCI, without diabetes, not treated with metformin,…
at UC Irvine
Intravenous Trappsol(R) Cyclo(TM) in Pediatric and Adult Patients With Niemann-Pick Disease Type C1
Sorry, in progress, not accepting new patients
A prospective, randomized, double-blind, placebo controlled, multi-center therapeutic study for patients age 3 and older with confirmed diagnosis of Niemann Pick disease type C1 (NPC1). The objective of this study is to evaluate the safety,…
at UCSF
RewinD-LB - Clinical Study of Neflamapimod in Patients with Dementia with Lewy Bodies
Sorry, in progress, not accepting new patients
The purpose of this study is to determine whether neflamapimod can improve learning skills, problem solving skills, and memory loss in people diagnosed with DLB. More specifically, improvement in verbal learning, memory, and attention, as well as…
at UCSD
Speech-Language Treatment with Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive Aphasia
Sorry, in progress, not accepting new patients
Primary progressive aphasia (PPA) is a disorder characterized by gradual decline in speech-language ability caused by underlying neurodegenerative disease. PPA is a devastating condition that can affect adults as young as their 50's, depriving them…
at UCSF
Brain Health Study: A Pragmatic, Patient-Centered Trial
Sorry, in progress, not accepting new patients
The eRADAR Brain Health Study seeks to refine and test a novel, low-cost strategy for increasing dementia detection within primary care.
at UCSF
Care Ecosystem Consortium Effectiveness Study
Sorry, in progress, not accepting new patients
The Care Ecosystem is an accessible, remotely delivered team-based dementia care model, designed to add value for patients, providers and payers in complex organizational and reimbursement structures. Care is delivered via the phone and web by…
at UCLA UCSF
INSPIRE Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement
Sorry, not yet accepting patients
The INSPIRE Study, initiated by the Healthy Minds Initiative, is a community-based research project aimed at demonstrating the impact of lifestyle factors on cognitive health and the prevention of dementia. Conducted in collaboration with the…
at UCLA
Treatment for Speech and Language in Primary Progressive Aphasia
Sorry, in progress, not accepting new patients
Primary progressive aphasia (PPA) is a progressive neurological disorder that causes a gradual decline in communication ability as a result of selective neurodegeneration of speech and language networks in the brain. PPA is a devastating condition…
at UCSF
Parkinson's and Zoledronic Acid
Sorry, in progress, not accepting new patients
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 …
at UC Davis UC Irvine UCLA UCSF
Diagnostic Test for Dementia With Lewy Bodies
Sorry, in progress, not accepting new patients
The Syn-D Study will be evaluating α-synuclein in patients with suspected MCI-AD and MCI-DLB. Using a simple diagnostic test will improve clinical accuracy in diagnosing, earlier diagnosis, and distinguish between neurodegenerative diseases.
at UCSD
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Sorry, in progress, not accepting new patients
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems. Alzheimer's disease and other dementias leave…
at UC Davis UCLA UCSF
Early Access Program With Arimoclomol in US Patients With NPC
Sorry, not accepting new patients
NPC is a rare, relentlessly progressive, neurological disease and associated with serious morbidity and shortened life expectancy. The purpose of this Expanded Access Program is to provide early access to arimoclomol for patients with Niemann-Pick…
at UCSF
Environmental and Reproductive Health Risk for Lewy Body Dementia
Sorry, in progress, not accepting new patients
The goal of this survey study is to identify environmental, occupational and reproductive health risk factors for Lewy body dementia, which includes Parkinson's disease dementia and dementia with Lewy bodies. Participants will complete a one-time…
at UCSD
Neurofilament Surveillance Project (NSP)
Sorry, in progress, not accepting new patients
This is a biomarker study designed to collect and analyze blood specimens from individuals carrying known familial frontotemporal lobar degeneration (f-FTLD) mutations compared to a control group of individuals without known f-FTLD mutations. The…
at UCSF
North American Prodromal Synucleinopathy Consortium
Sorry, accepting new patients by invitation only
This study will enroll participants with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
at UCLA
Phenotype, Genotype & Biomarkers in ALS and Related Disorders
Sorry, accepting new patients by invitation only
The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP),…
at UCSD
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
Sorry, in progress, not accepting new patients
There is a major unmet need for timely, non-invasive, and low-burden evaluation of patients presenting with mild cognitive impairment (MCI) and dementia. MCI impacts 12-18% of people in the United States over age 60 years (Alzheimer's Association.…
at UCSF
Diabetes Prevention Program Outcomes Study AD/ADRD Project
Sorry, accepting new patients by invitation only
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment…
at UCLA UCSD
DIAGNOSE CTE Research Project-II
Sorry, not yet accepting patients
Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports. RHI can result in concussions and asymptomatic non-concussions to confer risk for Alzheimer's disease (AD) and related dementias (ADRD) including…
at UCSF
Our lead scientists for Dementia research studies include Peter Ljubenkov, MD Jason Hinman, MD, PhD Deborah Barnes, PhD Rebecca S Boxer, MD, MS Mario F. Mendez, MD, PhD Bijan Najafi, PhD Pauline Wu, DO Adam Boxer, MD, PhD Doug Galasko Katherine Mun, MD Joel Kramer, PhD Michael D Geschwind, MD Veronica Yank, MD Katherine Possin, PhD Virginia Kimonis, MD Marie Kim, MD, PhD Aaron Colverson, PhD David K Johnson, PhD Caroline Hastings, MD Howie Rosen, MD Ji Won Choi, PhD David Wilson, MD, PhD Alon Avidan, MD, MPH.
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