Seizures clinical trials at University of California Health
21 in progress, 9 open to eligible people
Levetiracetam in the Treatment of Neonatal Seizures
open to eligible people ages up to 1 month
The main purpose of this study is to determine the maximum safe tolerated dose of LEV in the treatment of neonatal seizures. Our hypothesis is that optimal dosing of Levetiracetam (LEV) to treat neonatal seizures is significantly greater than…
at UCSD
XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
open to eligible people ages 18 years and up
The X-TOLE3 Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and tolerability of XEN1101 administered as adjunctive therapy in focal-onset seizures.
at UC Irvine
Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy
open to eligible people ages 1 month to 18 years
The purpose of the study is to evaluate the efficacy of perampanel as measured by the 50 percent (%) responder rate during the maintenance period of the core study for seizure frequency in participants with pediatric epileptic syndrome (Cohort 1)…
at UCLA
XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
open to eligible people ages 12 years and up
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of XEN1101 administered as adjunctive treatment in primary generalized tonic-clonic seizures (PGTCS).
at UC Davis UC Irvine
Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures
open to eligible people ages 12 years and up
The purpose of the study is to assess the success of a single administration of Staccato alprazolam compared with placebo both in rapidly terminating a seizure episode within 90 seconds and with no recurrence of seizure(s) up to 2 hours after…
at UCLA
buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest
open to eligible people ages 18 years and up
RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.
at UCSF
Pediatric Dose Optimization for Seizures in Emergency Medical Services
open to eligible people ages 6 months to 13 years
The Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE) study is designed to improve how paramedics treat seizures in children on ambulances. Seizures are one of the most common reasons why people call an ambulance for…
at UC Davis UCSF
PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest
open to eligible people ages 18 years and up
Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients. The investigators are proposing a pilot randomized placebo-controlled clinical…
at UCSF
Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
open to all eligible people
The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of post-neonatal…
at UCSF
LP352 in Children and Adults With Dravet Syndrome (DS)
Sorry, not currently recruiting here
This (DEEp SEA Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DS. The study consists of 3 main…
at UCLA
LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)
Sorry, not currently recruiting here
This (DEEp OCEAN Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DEE. The study consists of 3 main…
at UCLA
LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
Sorry, not currently recruiting here
This (DEEp OLE Study) is a multicentre, open-label study to investigate the long-term safety, efficacy, tolerability, and pharmacokinetics (PK) of LP352 in the treatment of seizures in children and adults with DEE who completed Study LP352-301 or…
at UCLA
ZX008 in Subjects With CDKL5 Deficiency Disorder
Sorry, in progress, not accepting new patients
This is a multicenter, double-blind, parallel-group, placebo controlled, 2-part study to evaluate the efficacy and safety of ZX008 when used as adjunctive therapy for the treatment of uncontrolled seizures in children and adults with…
at UCLA
Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome
Sorry, in progress, not accepting new patients
This is an international, multicenter, open-label, long-term safety study of ZX008 in subjects with Dravet syndrome, Lennox-Gastaut syndrome or epileptic encephalopathy
at UCLA
Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures
Sorry, accepting new patients by invitation only
The purpose of the study is to evaluate the long-term safety and tolerability of Staccato alprazolam.
at UCLA
of XEN1101 in Epilepsy
Sorry, accepting new patients by invitation only
This study will evaluate the long term safety, tolerability, pharmacokinetics (PK), and efficacy of XEN1101 in subjects with Focal Onset Seizures (FOS) or Primary Generalized Tonic-Clonic Seizures (PGTCS) for the treatment of seizures for up to 3…
at UC Irvine
Cenobamate Open-Label Extension Study for YKP3089C025
Sorry, accepting new patients by invitation only
52 Week Open-Label Safety Study of Cenobamate for Subjects who Complete YKP3089C025 (core study)
at UCSD
Epilepsy Cycles Longitudinal Monitoring to Inform Personalized Seizure-risk Estimation (ECLIPSE)
Sorry, accepting new patients by invitation only
The occurrence of seizures in epilepsy is not entirely random. Temporal patterns that organize the occurrence of seizures over weeks and months were previously unraveled using intracranial EEG System (IEEG) that monitors epileptic brain activity…
at UCSF
RNS System LGS Feasibility Study
Sorry, in progress, not accepting new patients
To generate preliminary safety and effectiveness data for brain-responsive neurostimulation of thalamocortical networks as an adjunctive therapy in reducing the frequency of generalized seizures in individuals 12 years of age or older with Lennox…
at UCSF
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate the long-term safety in patients with TSC and refractory seizures who are currently receiving everolimus treatment in the Novartis-sponsored EXIST-3 study and who are determined to be benefiting from…
at UCLA UCSF
Role of Inflammation in Neonatal Epileptogenesis
Sorry, in progress, not accepting new patients
The purpose of this study evaluate the relationship between inflammation and epilepsy in neonates with seizures after birth.
at UCSF
Our lead scientists for Seizures research studies include Adam L Numis, MD Rajsekar R. Rajaraman, MD, MS Edilberto Amorim, MD Hannah C Glass, MDCM, MAS.
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