Sepsis clinical trials at University of California Health
8 in progress, 5 open to eligible people
Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial
open to eligible people ages 18 years and up
The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy for the treatment of Gram-Negative BloodStream…
at UCSF
TIN816 in Sepsis-associated Acute Kidney Injury (SA-AKI)
open to eligible people ages 18-85
The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting with a diagnosis of…
at UCSF
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
open to eligible people ages 2 months to 17 years
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether balanced fluid…
at UC Davis UCSF
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
open to eligible people ages up to 17 years
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ…
at UC Davis UCSF
Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch
open to eligible people ages 18 years and up
The goal of this observational study is to learn about the utility of biopatches predicting 30-day readmissions in patients discharged from the hospital with sepsis. The main question[s] it aims to answer are: • Does the application of a biopatch…
at UCSD
GM-CSF for Reversal of immunopAralysis in pediatriC sEpsis-induced MODS Study
Sorry, in progress, not accepting new patients
This study is an open-label, multi-center, interventional trial in which children with sepsis-induced MODS undergo surveillance immune function testing beginning on Day 2 of MODS. Those children who demonstrate immunoparalysis (TNF-alpha response…
at UCLA UCSF
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
Sorry, accepting new patients by invitation only
This protocol will collect real-world data retrospectively from the electronic health record (EHR) as data obtained from the delivery of routine medical care to develop a machine learning (ML)-based Clinical Decision Support (CDS) system for severe…
at UC Irvine
APS Phenotyping Study
Sorry, not currently recruiting here
The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of…
at UCSF
Our lead scientists for Sepsis research studies include Sarah Doernberg, MD Gabriel Wardi Matthieu Legrand.
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