Summary

for people ages 18-70 (full criteria)
at UC Irvine
study started
estimated completion:
Stephanie Tjen-A-Looi (uci) Liang-Wu Fu (uci) Shaista Malik (uci) LiFang Xie (uci)

Description

Summary

Based on previous published research in animals, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.

Official Title

Neural Mechanism of the Effect of Acupuncture on Myocardial Ischemia

Details

The purpose of this study is to prove: (1) Myocardial ischemia, cardiac arrhythmias and hypertensive response at rest and provoked by stress are decreased by EA; (2) The mechanism of the ischemic response is an imbalance between myocardial oxygen supply and demand originating as an increase in autonomic nervous system sympathetic activity causing increased oxygen demand. EA inhibits the sympathetic nervous system, decreases blood pressure and reduces the oxygen demand. Our prior data in animals shows that improvements in cardiovascular function during myocardial ischemia are mediated by an EA-induced sensory neural reflex originating in somatic nerves to reduce sympathetic nerve activity. The specific aims of the present study will allow us to better understand and modulate the sympathetic nervous discharge activity that can precipitate coronary ischemia, arrhythmias and hypertension in exercise stress in humans. The potential clinical application is the therapeutic value of EA in patients with hypertension.

Furthermore, the study will also investigate gender differences in the blood pressure lowering effect of EA. In particular in middle-aged hypertensive women.

Keywords

Hypertension Arrhythmias blood pressure mild to moderate hypertension Electro-acupuncture control Electro-acupuncture test

Eligibility

You can join if…

Open to people ages 18-70

  • Patients with mild coronary disease, and no significant ECG change reflecting ischemia at rest

You CAN'T join if...

  • Pregnant or nursing women
  • Individuals with severe coronary disease (continuous angina)
  • Conduction abnormalities on ECG consistent with left bundle branch block
  • Cardiac arrhythmias associated with low blood pressure (90 mmHg)
  • Peripheral vascular disease
  • Orthopedic disease
  • Diabetic or psychological illness that could interfere with safe performance of exercise of psychophysiological stress testing
  • Those with known sensitivity to topical preparations or strong reactions to medical dressings and skin tapes

Location

  • Susan Samueli Integrative Health Institute accepting new patients
    Costa Mesa California 92626 United States

Lead Scientists

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Irvine
ID
NCT00932139
Study Type
Interventional
Last Updated