E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

a study on Nicotine Electronic Cigarettes Tobacco

Summary

Eligibility
for people ages 21-45 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCLA
Dates
study started
estimated completion
Principal Investigator
by Holly R Middlekauff (ucla)

Description

Summary

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, nicotine inhaler, and sham-control on endothelial function, oxidative stress and sympathetic nerve activity

Official Title

The Effects of Electronic Cigarettes on Endothelial Function and Oxidative Stress

Details

Participants will have an acute exposure on 4 occasions1) e-cigarette with nicotine, 2) e-cigarette without nicotine, 3) nicotine inhaler, 4) sham control and undergo ECG recording for heart rate variability, endothelial function measurement using ultrasound ("FMD") and blood tests for oxidative stress markers.

Keywords

Nicotine Dependence, nicotine, sympathetic nerve activity, oxidative stress, Tobacco Use Disorder, e-cig with nicotine, e-cig without nicotine, nicotine inhaler, Nicotine inhaler: use a nictoine inhaler

Eligibility

You can join if…

Open to people ages 21-45

- Healthy

You CAN'T join if...

  • Cardiac disease
  • Respiratory disease
  • Diabetes mellitus

Locations

  • UCaliforniaLA withdrawn
    Los Angeles California 90095 United States
  • UCaliforniaLA accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at University of California Health

  • Holly R Middlekauff (ucla)
    Professor, Medicine. Authored (or co-authored) 120 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT03072628
Study Type
Interventional
Participants
Expecting 120 study participants
Last Updated