Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

Open to people ages 21-70

• Healthy on the basis of medical history and limited physical examination-
  • Heart rate < 105 beats per minute (BPM)*.
  • Systolic Blood Pressure < 160 and > 90*.
  • Diastolic Blood Pressure < 100 and > 50*.
  • *considered out of range if both machine and manual readings are above/below these thresholds.
  • Body Mass Index <= 38.0.
• Current regular user of electronic cigarettes (EC)
  • EC device use at least 15 or more days in the past 30 days (with e- liquid >= 3mg/ml)
  • No restriction on flavor or type of e-cigarette used
  • Saliva cotinine >= 50 ng/ml and/or NicAlert = 6
• Age >= 21 years old <= 70 years old
• Willingness to abstain from drug use for the duration of the study

• The following unstable medical conditions:
  • Heart disease
  • Seizures
  • Cancer
  • Thyroid disease (okay if controlled with medication)
  • Diabetes
  • Hepatitis B or C or Liver disease
  • Glaucoma
  • Kidney disease or urinary retention
  • History of stroke
  • An ulcer in the past year
  • Active use of an inhaler for Asthma or chronic obstructive pulmonary disease (COPD)
• Medications
  • Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).
  • Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).
  • Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).
  • Any stimulant medications (example: Adderall) generally given for attention deficit hyperactivity disorder (ADHD) treatment.
• Other/Misc. Health Conditions
  • Oral thrush
  • Fainting (within the last 30 days)
  • Other "life threatening illnesses" as per principal investigator and/or study physician's discretion
• Pregnancy
  • Pregnancy (self-reported and urine pregnancy test)
  • Breastfeeding (determined by self-report)
  • Women of childbearing potential must be using an acceptable method of contraception
• Concurrent participation in another clinical trial.
• Inability to read and write in English
• Planning to quit smoking or vaping within the next 60 days
• A known propylene glycol/vegetable glycerin allergy
• Uncomfortable with getting blood drawn
• Recent onset or change (worsening) in cough, fever and/or abdominal symptoms (vomiting or pain) in the past two weeks