Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCSF
Dates
study started
completion around
Principal Investigator
by Tina Bhutani, MD (ucsf)
Headshot of Tina Bhutani
Tina Bhutani

Description

Summary

This study examines the effect of Goeckerman therapy (a combination of phototherapy and topical crude coal tar), crude coal tar alone, and phototherapy alone on the immunologic and genetic environment within psoriatic skin lesions.

Details

This is a three-arm, open-label study to examine the effect of Goeckerman therapy. Goeckerman therapy is known for its high efficacy and favorable safety profile in the treatment of psoriasis. It consists of a combination of phototherapy and topical crude coal tar). This study will examine how Goeckerman therapy, crude coal tar alone, and phototherapy alone affect the mmunologic and genetic environment within psoriatic skin lesions. Fifteen subjects with moderate to severe psoriasis will be enrolled. Biopsy samples will be collected and undergo molecular profiling to further elucidate the mechanism of action by which Goeckerman treatment improves psoriatic skin lesions.

Keywords

Psoriasis Vulgaris, Psoriasis, goeckerman, phototherapy, Coal Tar, Goeckerman Therapy, Crude Coal Tar Only, Phototherapy Only

Eligibility

Location

  • UCSF Psoriasis and Skin Treatment Center
    San Francisco California 94118 United States

Lead Scientist at University of California Health

  • Tina Bhutani, MD (ucsf)
    I am a dermatologist and clinical researcher in the Department of Dermatology at UCSF. I serve as co-director of the Psoriasis and Skin Treatment Center, a world-renowned clinic dedicated to the care of patients with psoriasis.

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT03662685
Phase
Phase 4 Psoriasis Research Study
Study Type
Interventional
Participants
Expecting 15 study participants
Last Updated