Chronic Kidney Disease clinical trials at University of California Health
30 in progress, 17 open to eligible people
REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease
open to eligible people ages 30-80
The purpose of this study is to assess the safety and efficacy (including durability) of up to 2 REACT injections given 3 months (+30 days) apart and delivered percutaneously into biopsied and non-biopsied contralateral kidneys in participants with…
at UC Davis
Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
open to eligible people ages 18-70
The purpose of this study is to determine whether vonsetamig will safely decrease anti-HLA antibodies to allow for kidney transplantation. Vonsetamig is being studied for treatment of patients in need of kidney transplantation who are highly…
at UC Irvine UCSF
ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE
open to eligible people ages 18-90
The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent …
at UCSF
Comparing Surgical and Endovascular Arteriovenous Fistula Creation
open to eligible people ages 18-99
Patients with end-stage kidney disease (ESKD) who use hemodialysis to filter their blood require vascular access for the dialysis machine; the most common type of vascular access is called an arteriovenous fistula (AVF). The AVF is a direct connect…
at UCLA
Ferric Citrate and Chronic Kidney Disease in Children
open to eligible people ages 6-18
We will conduct a 12-month, double-blind, randomized, placebo-controlled trial to assess the effects of therapy with ferric citrate (FC) on changes in intact FGF23 levels (iFGF23, primary endpoint) in 160 pediatric patients (80 in each of the two…
at UCLA UCSF
Retro-active Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-identical Kidney Transplants
open to eligible people ages 18 years and up
The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function through hematopoietic stem …
at UCLA
DCR-PHXC in Patients With PH1 and ESRD
open to all eligible people
The aim of this study is to evaluate DCR-PHXC in participants with PH1 and severe renal impairment, with or without dialysis.
at UCSF
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
open to eligible people ages 21-85
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility…
at UC Davis
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
open to eligible people ages 18 years and up
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be…
at UCSF
Ferric Citrate in Children With Hyperphosphatemia Related to Chronic Kidney Disease
open to eligible people ages 6-16
This study will be conducted to assess the safety and tolerability of ferric citrate in pediatric participants with hyperphosphatemia related to chronic kidney disease (CKD).
at UCSF
Arteriovenous Vascular (AV) ACCESS Trial
open to eligible people ages 60 years and up
This study is to prospectively compare the effectiveness and safety of the two types of arteriovenous access placement (fistula or graft) in older adults with end stage kidney disease and multiple chronic conditions
at UCLA
Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
open to eligible people ages 45 years and up
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m^2 or…
at UCLA
Home Blood Pressure (BP) Trial
open to eligible people ages 18 years and up
The main study will be a two arm 10-month, cross-over randomized controlled trial of 200 participants treated with end-stage-kidney-disease treated with in-center hemodialysis in the Seattle and San Francisco area comparing a strategy of targeting…
at UCSF
Compare the Efficacy and Safety of the ATEV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis
open to eligible females ages 18 years and up
The goal of this clinical trial is to compare the number of catheter-free days (CFD) and the rate and severity of any dialysis access-related infections between the ATEV and AVF groups over 12 months in patients with end-stage renal disease (ESRD)…
at UCSD
APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)
open to all eligible people
The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a…
at UCLA UCSF
Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
open to eligible people ages 18-70
The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study (NCT05092347). No study drug will be given…
at UC Irvine UCSF
Decellularized Femoral Artery Allograft (Nexeon AVX) Prospective Registry
open to eligible people ages 18 years and up
Post market registry to assess the safety and efficacy of a novel decellularized human femoral artery allograft (Nexeon AVX Decellularized Femoral Artery,
at UCLA
Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis
Sorry, in progress, not accepting new patients
The main purpose of this study is to compare the Human Acellular Vessel (HAV) with arteriovenous fistula (AVF) when used for hemodialysis access
at UC Davis UC Irvine UCLA UCSD
Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Sorry, in progress, not accepting new patients
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk. The study will last approximately 2…
at UCLA
Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
Sorry, not currently recruiting here
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and…
at UCSD
Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
Sorry, not currently recruiting here
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and…
at UCSD
Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease
Sorry, in progress, not accepting new patients
Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic…
at UCLA
CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease
Sorry, not currently recruiting here
Frailty and sarcopenia are modifiable risk factors for morbidity and mortality in patients with ESRD. Exercise is the recommended intervention to prevent frailty and sarcopenia, however, many clinical trials have shown limited clinical improvement…
at UC Davis
Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD
“Adults ages 30-80 with Chronic Kidney Disease can participate in a new exercise study to help improve muscle function. See if you qualify!”
Sorry, in progress, not accepting new patients
Skeletal muscle dysfunction (sarcopenia) is an under-recognized target organ complication of CKD with substantial adverse clinical consequences of disability, hospitalization, and death. Sarcopenia in this proposal is defined by impaired metabolism…
at UC Davis
Expanding and Promoting Alternative Care and kNowledge in Decision-making Trial
Sorry, not currently recruiting here
The goal of this clinical trial is to compare two health system-based approaches for offering kidney failure treatment options to older patients with kidney failure, specifically, to ensure patients are actively involved in a shared decision making…
at UCSF
Immunological Tolerance in Patients With Mismatched Kidney Transplants
Sorry, in progress, not accepting new patients
This study seeks to determine if administration of the drug belumosudil (KD025) will be safe and improve transplant tolerance in subjects undergoing combined Human Leukocyte Antigen (HLA) single haplotype-matched related or 0-3 antigen (at A, B, C,…
at UCLA
Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
Sorry, accepting new patients by invitation only
In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in Diabetes (PLAFOND) diet…
at UC Irvine UCLA
Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score
Sorry, in progress, not accepting new patients
The TEAMMATE Trial will enroll 210 pediatric heart transplant patients from 25 centers at 6 months post-transplant and follow each patient for 2.5 years. Half of the participants will receive everolimus and low-dose tacrolimus and the other half…
at UCLA
SDCC - Prospective Cohort Study of Chronic Renal Insufficiency
Sorry, in progress, not accepting new patients
Chronic kidney disease (CKD) is a silent epidemic affecting more than 37 million Americans. The burden of morbidity and mortality associated with CKD derives from its frequent progression to end-stage kidney disease (ESKD) and the disproportionate…
at UCSF
VIRTUUS Children's Study
Sorry, in progress, not accepting new patients
The objective of the VIRTUUS Children's Study is to adapt identified and validated adult noninvasive diagnostic and prognostic biomarkers for the characterization of allograft status in pediatric recipients of kidney allografts.
at UCLA UCSD
Our lead scientists for Chronic Kidney Disease research studies include Karen Woo, MD, PhD Javier Lopez, MD Sammy Elmariah, MD, MPH Chi-yuan Hsu, MD Baback Roshanravan, MD Isidro B. Salusky, MD Erik Lum Suphamai Bunnapradist, MD, MS Dianne S. Cheung, MD, MPH Harini Sarathy, MD Jeffrey L. Veale, MD.
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