Summary

Eligibility
for people ages 21-45 (full criteria)
Location
at UCLA
Dates
study started
estimated completion
Principal Investigator
by Holly R Middlekauff, MD (ucla)

Description

Summary

Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization and inflammation/oxidative stress.

Official Title

Acute Impact of Switching From Tobacco Cigarettes to E-Cigarettes in People Living With HIV

Details

On separate days, participants will undergo 3 different exposures: an acute e-cigarette exposure, an acute tobacco cigarette exposure, and a sham (empty e-cigarette) control . Before and after the acute exposure, participants will have blood drawn for inflammation/oxidative stress markers and undergo a 5-minute ECG recording.

Keywords

E Cigarette Use Vaping Smoking Tobacco Smoking Nicotine Use Disorder Qt Interval, Variation in HIV I Infection Oxidative Stress Inflammation Tobacco Use Disorder TCIG ECIG PLWH smoker

Eligibility

You can join if…

Open to people ages 21-45

Chronic (> 1year) TCIG smoker HIV positive Stable ART Viral count non-detectable CD4 >500

You CAN'T join if...

Known major illness (heart disease, diabetes, lung or liver disease) Daily recreational drug use, including cannabis >2 alcoholic drinks per day Obesity (>30 kg/m2) Recent (<3 months) infection

Locations

  • UCLA accepting new patients
    Los Angeles California 890095 United States
  • UCaliforniaLA accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at University of California Health

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT04568395
Study Type
Interventional
Last Updated