Autism clinical trials at University of California Health
24 in progress, 12 open to eligible people
Disparities in Autism Spectrum Disorder Diagnosis Using a Direct-to-home Telemedicine Tool
open to eligible people ages 18 months to 42 months
The investigators propose to evaluate the use of a telemedicine tool, the TELE-ASD-PEDS (TAP), that is designed to assess for autism spectrum disorder (ASD) symptoms in toddlers. The TAP was developed at VUMC by a team of clinical psychologists with …
at UC Davis
AWARE: Management of ADHD in Autism Spectrum Disorder
open to eligible people ages 4-17
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism. Using a sequential, multiple assignment …
at UC Irvine
Boosting Language Outcomes of Minimally Verbal Children With ASD (BLOOM)
open to eligible people ages 48 months to 66 months
In this project, the investigator will test the effect of augmenting an evidence based joint attention intervention (JASPER) with a motor-sound system intervention (PROMPT) compared to JASPER only on speech and language outcomes. The investigator…
at UCLA
CBT for Youth With Autism and Emotional/Behavioral Needs in Community Care Settings
open to eligible people ages 6-14
This study is a 4-year randomized, controlled trial comparing cognitive behavioral therapy (CBT) to usual clinical care for children (aged 6-14 years) with autism and emotional dysregulation (e.g., irritability, anxiety). We will randomly assign 50…
at UCLA
Evaluating BOSCC and ELSA as Outcome Measures in the Context of a JASPER Intervention Trial
open to eligible people ages 18 months to 5 years
Research teams in Boston University, UCLA, and Weill Cornell will recruit 90 participants in 3 years (10 participants per site per year) and evaluate JASPER, play-based intervention, using the BOSCC and ELSA-T. Participants will be randomized to…
at UCLA
Early Start Denver Model in Community Programs Serving Young Autism
open to eligible people ages 12 months and up
This study tests the effectiveness of the Early Start Denver Model (ESDM) in community agencies that serve young autistic children. The feasibility, usability and acceptability of the model will be explored. Understanding effectiveness of new…
at UC Davis
Family, Responsibility, Education, Support, and Health for Families With a Child With Autism
open to eligible people ages 6-12
The objective of this proposed study is to collect initial efficacy data on a telehealth parent-based behavioral program for children with autism and overweight or obesity (PBT-A), compared with health education (HE).
at UCSD
Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services
open to eligible people ages 6-99
This project aims to follow up on a prior project examining the impact of training therapists in an executive functioning intervention Unstuck and On Target (UOT) adapted for community mental health settings. Study aims are to test the clinical and…
at UCSD
PRISM Intervention Study
open to eligible people ages 36 months to 59 months
This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as…
at UCLA
ABC-CT Pre-School Feasibility Study
open to eligible people ages 3-5
This is a multicenter study that aims to determine whether the EEG and ET experiments studied in the ABC-CT Phase 1 and ABC-CT Confirmation studies can be successfully used with 3-5-year-old children and to determine the viability of these measures…
at UCLA
Individuals With Autism and Germline Heterozygous PTEN Mutations
open to eligible people ages 18 months and up
The purpose of this study is to determine cross-sectional and longitudinal medical, behavioral, and cognitive differences between PTEN ASD and other groups, as well as to identify cognitive, neural systems, and molecular biomarkers specific to PTEN…
at UCLA
Autism Biomarkers Consortium for Clinical Trials: Confirmation Study
open to eligible people ages 6-11
This is a multicenter longitudinal study that aims to validate a set of measures that were previously identified as promising candidate biomarkers and/or sensitive and reliable objective measures of social function in ASD for potential use in…
at UCLA
AIR-B4: Mind the Gap
Sorry, in progress, not accepting new patients
The AIRB research team will compare the use and effectiveness of each intervention (Mind the Gap, Remaking Recess and Self Determination Learning Model of Instruction) with and without the addition of an implementation strategy, UNITED. In all…
at UC Davis
AIRB-4: Self-Determined Learning Model of Instruction
Sorry, in progress, not accepting new patients
The AIRB research team will compare the use and effectiveness of each intervention (Mind the Gap, Remaking Recess and Self Determined Learning Model of Instruction) with and without the addition of our implementation strategy, UNITED. In all groups, …
at UC Davis
CM-AT for the Treatment of Children With Autism
Sorry, in progress, not accepting new patients
This is a Phase III, open label extension study evaluating the continued safety and efficacy of CM-AT in pediatric patients with autism with all levels of fecal chymotrypsin.
at UCSF
Effectiveness Trial of Mobile ESI for Toddlers With Autism Identified by Early Screening in Primary Care
Sorry, not currently recruiting here
The goal of this collaborative R01 is to demonstrate the therapeutic value and community-wide implementability of an early intervention (EI) platform for toddlers with autism spectrum disorder (ASD) that is completely virtual, from recruitment…
at UCLA
Telehealth-Based ASD Assessments and Supports on Child and Caregiver Outcomes
Sorry, in progress, not accepting new patients
The overall goal of this study is to evaluate telehealth and internet-based approaches to meet accessibility challenges for families with concerns about ASD in their infants. In this study, we will gather exploratory data related to the potential of …
at UC Davis
Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate the long-term safety and tolerability of cariprazine in the treatment of pediatric participants with schizophrenia, bipolar I disorder, or autism spectrum disorder (ASD) and to establish the benefit-risk…
at UCSD
Proof of Mechanism Study for the Treatment of Social Anhedonia in ASD
Sorry, in progress, not accepting new patients
This project will use the experimental medicine approach of a Phase IIa Proof of Mechanism 16-week, randomized, double-blind, controlled trial of L-DOPA versus placebo administration in combination with a 16 week social skills training group in…
at UCLA
School-based Paraeducator Education for Engagement At Recess
Sorry, not currently recruiting here
The purpose of the proposed three-site study is to test whether an educator-level implementation strategy, coaching, with or without a school-level implementation strategy, school-based teams, will maximize paraeducators' use (fidelity and…
at UCLA
Testing an Evidence-Based Supported Employment Model in Autistic Young Adults
Sorry, not yet accepting patients
This study aims to enhance employment outcomes for young adults with autism and intellectual and developmental disabilities (IDD) through the implementation of an evidence-based supported employment model known as Individual Placement and Support…
at UC Davis
Translating Evidence-based Interventions for ASD: Multi-Level Implementation Strategy
Sorry, accepting new patients by invitation only
The purpose of this study is to test the effectiveness of the "Translating Evidence-based Interventions (EBI) for ASD: Multi-Level Implementation Strategy" (TEAMS) model on provider-level implementation outcomes when used to enhance provider…
at UC Davis UCLA UCSD
Cannabidiol to Treat Severe Behavior Problems in Children With Autism
Sorry, in progress, not accepting new patients
There are very few treatments that are effective in reducing severe behavioral problems associated with autism. These behaviors include aggressive and self-harm behaviors, frequent repetitive behaviors and severe hyperactivity. This study is being…
at UCSD
Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)
Sorry, in progress, not accepting new patients
The purpose of this study is to characterize the developmental phenotype of ASD and ID and to identify biomarkers using advanced MRI methodology and electrophysiological biomarkers of synaptic function and connectivity predictive of ASD and ID…
at UCLA
Our lead scientists for Autism research studies include Meagan Talbott, Ph.D. Kerri Boutelle, PhD Aubyn C Stahmer, PhD Peter Chung, MD Marjorie Solomon, PhD, MBA Sally Ozonoff, Ph.D. Rajsekar R. Rajaraman, MD, MS Robert Hendren, DO Julian A. Martinez, MD, PhD Doris Trauner, MD.
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