Do Endotypes Predict Response and Sequelae in OSA Patients

Open to people ages 21-65

• Ages 21-65 years old
• Men and women with a physician diagnosis of OSA (or strongly suspected to have sleep apnea - * see below)
• BMI 20 - 35 kg/m2

• Pregnancy (current or planned)
• Nursing
• Inability to provide self-consent or complete study procedures, such as questionnaires that are only available/validated in English.
• Already on effective therapy and adherent to treatment for OSA
• Other known untreated sleep fragmenting disorder, such as periodic limb movement disorder, or narcolepsy
• Circadian rhythm disorder
• Unrevascularized coronary artery disease, angina, prior heart attack or stroke, congestive heart failure
• Uncontrolled hypertension (systolic blood pressure >160, diastolic blood pressure >95)
• Chronic lung disease requiring the use of supplemental oxygen, or with evidence of hypercapnia due to obstructive lung disease.
• Presence of tracheostomy
• Hospitalization within the past 90 days
• Prior peptic ulcer disease, esophageal varices, or gastrointestinal bleeding (< 5 years)
• Prior gastric bypass surgery
• Chronic liver disease or end-stage kidney disease
• Active cancer
• Allergy to any of the study drug
• Regular use of medications known to affect control of breathing (opioids, sedatives/hypnotics including benzodiazepines, theophylline)
• Chronically using study drug (Eszopiclone)
• Active illicit substance use
• Alcohol use of >1 standard drink/night for women or >2 standard drinks/night for men nightly alcohol use
• Active smoking or vaping within the past 6 months
• Psychiatric disease, other than controlled depression/anxiety
• Prisoners
  • Subjects who are strongly suspected to have sleep apnea will be offered an overnight home sleep apnea test (HSAT) to verify OSA diagnosis.