for males ages 18 years and up (full criteria)
Healthy Volunteers
healthy people welcome
study started
completion around
Principal Investigator
by Cherie Blair (ucla)



This clinical trial aims to investigate the effects of a decline in methamphetamine use on rectal inflammatory cytokine levels, substance use contexts, and HIV/STI risk behavior. This clinical trial also seeks to evaluate joint effects of methamphetamine use and rectal gonorrhea/chlamydia infection on rectal inflammatory cytokine levels. The proposed trial will consist of 40 MSM, half with rectal gonorrhea/chlamydia infection at enrollment (n=20), with methamphetamine use disorder that will receive contingency management for methamphetamine reduction. Following baseline measurement, participants will be observed over the course of 8 weeks, where participants will complete behavioral surveys, provide urine for drug testing, and rectal samples for measurement of rectal inflammatory cytokine levels.

Official Title

Effects of Methamphetamine Use on Risk Behavior, Systemic and Mucosal Inflammation, and Sexually Transmitted Infection (STI)/HIV Risk Among Men Who Have Sex With Men


Methamphetamine-dependence, Rectal Gonorrhea, Rectal Chlamydia, Gonorrhea, Inflammation, Contingency Management


You can join if…

Open to males ages 18 years and up

  • Cisgender male
  • 18 years of age or older
  • Understand written and spoken English
  • Condomless receptive anal intercourse in past 90 days
  • Meet DSM-5 criteria for methamphetamine use disorder
  • Positive urine toxicology screen for MA metabolites at study entry
  • Negative rectal GC/CT screen (n=20) or Positive rectal GC and/or CT screen (n=20)
  • Able to provide written informed consent and willing/able to complete study visits.

You CAN'T join if...

  • Reports current treatment for another substance use disorder
  • Positive test for opioids, cocaine, and/or hallucinogens
  • Treatment for gonorrhea and/or chlamydia infection in past 3 months
  • Presence of a condition that in the opinion of the investigator would compromise the safety of the patient or the quality of the data


  • UCLA Vine Street Clinic
    Los Angeles California 90038 United States

Lead Scientist at University of California Health

  • Cherie Blair (ucla)
    HS Assistant Clinical Professor, Medicine. Authored (or co-authored) 8 research publications


in progress, not accepting new patients
Start Date
Completion Date
University of California, Los Angeles
Study Type
Expecting 30 study participants
Last Updated