Substance Abuse clinical trials at University of California Health

28 in progress, 19 open to eligible people

Showing trials for

  • Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

    open to eligible people ages 18 years and up

    VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous (in the belly area) formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence…

    at UCSF

  • Age-dependent Effects of Smoked and Oral Delta-9-THC

    open to eligible people ages 18-65

    This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.

    at UCLA

  • AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)

    open to eligible people ages 21-55

    This study will assess the analgesic, appetite-stimulating, and subjective effects of cannabigerol (CBG) alone and in combination with THC.

    at UCLA

  • Analgesic and Subjective Effects of Terpenes

    open to eligible people ages 21-55

    The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.

    at UCLA

  • ASK-PrEP (Assistance Services Knowledge-PrEP)

    open to eligible males ages 18 years and up

    ASK-PrEP is a two-arm randomized controlled trial (RCT), with a Stepped Care approach, among HIV-negative trans women and men who have sex with men with a substance use disorder (SUD). Participants will be randomized (3:1) to the ASK-PrEP Stepped…

    at UCLA

  • Cannabis Effects as a Function of Sex (CanSex)

    open to eligible people ages 21-55

    The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women

    at UCLA

  • Collaborative Care for Polysubstance Use in Primary Care Settings (Co-Care)

    open to eligible people ages 18 years and up

    The purpose of this trial is to test the efficacy of a collaborative care intervention to address opioid- and/or stimulant-involved polysubstance use in adult primary care patients with moderate to severe substance use disorders (SUD). The primary…

    at UCLA

  • Contingency Management for Veteran Smokers Undergoing Major Elective Surgery

    open to eligible people ages 18 years and up

    The goal of this study is to design and test the first mobile contingency management (CM) smoking cessation intervention for military Veterans undergoing major elective surgery. Smoking is the leading risk factor for postoperative complications and…

    at UCSF

  • Cultural Adaptation of Drug Treatment for DJJ Youth

    open to eligible people ages 12-17

    This project aims to improve the understanding of the impact of Ethnic and Racial Discrimination (ERD) on adolescent alcohol and other drug use (AOD) within the Black Justice-Involved Youth (JIY) population. Individual interviews with Black JIY and…

    at UCSF

  • Smoked THC and CBD in Men and Women

    open to eligible people ages 21-55

    The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.

    at UCLA

  • Expression of Stress Markers During Meth Treatment (EXPRESS+)

    open to eligible males ages 18-45

    This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive people assigned male …

    at UCLA

  • Intervention for Virologic Suppression in Youth

    open to eligible people ages 18-29

    The goal of this randomized clinical trial is to test the effect of a technology-based intervention with an Adaptive Treatment Strategy (ATS) among youth living with HIV (YLWH) (18-29 years old). This piloted and protocolized intervention combines:…

    at UCSF

  • Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women

    open to eligible females ages 18 years and up

    Trauma exposure, posttraumatic stress disorder (PTSD), and substance use disorder (SUD) present major threats to public health. PTSD and SUD are major correlates of disability, often resulting in severe social and occupational impairment.…

    at UCLA

  • Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

    open to eligible people ages 18-99

    The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors…

    at UCSF

  • OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

    open to eligible people ages 18 years and up

    Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in…

    at UCSD

  • Patient Decision Aid for Opioid Use Disorder

    open to eligible people ages 18 years and up

    The aim of the study is to test the effectiveness of the Patient Decision Aid for Opioid Use Disorder (PtDA-MAT) by conducting a stepped-wedge cluster-randomized trial in CA H&SS (stratified by rural vs. non-rural areas) for adults with OUD. Patient …

    at UCLA

  • Smoking Cessation CM for Veterans With or at Risk for Cancer

    open to eligible people ages 18 years and up

    Tobacco use among US Veterans poses significant health problems and challenges to their overall well-being. The aim of this project is to evaluate the effectiveness of a program called Contingency Management (CM) in helping Veterans quit smoking…

    at UCSF

  • Technology to Reduce Youth Substance Use

    open to eligible people ages 13-18

    The research project will focus on conducting a trial of whether a tailored SMS text-messaging intervention is efficacious in improving justice-involved youths' substance use or dual diagnosis treatment attendance and engagement.

    at UCSF

  • Women Focused Encounters for Resilience Independence Strength and Eudaimonia

    open to eligible females ages 18 years and up

    The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and comittment therapy(ACT) + exercise + social support to address the substance (ab)use, violence, and…

    at UCSD

  • Test Whether BI 1356225 Improves Impulsive Behavior in Men With Opioid Use Disorder Who Are Taking Buprenorphine

    Sorry, not currently recruiting here

    This study is open to men between 18 and 65 years of age with opioid use disorder. Opioid use disorder is also called opioid addiction or opioid dependence. People can join the study if they currently take a medicine called buprenorphine. People…

    at UCLA

  • Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression

    Sorry, currently not accepting new patients, but might later

    The purpose of this study is to examine the feasibility of a protocol in which individuals with comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete Amplification of Positivity for Alcohol Use Disorder…

    at UCSD

  • Oral THC and CBD in Men and Women

    Sorry, not yet accepting patients

    The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of oral delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.

    at UCLA

  • FostrSpace-CASA R61/R33

    Sorry, in progress, not accepting new patients

    The purpose of this study is to understand how an online digital health application (app) called FostrSpace can reduce substance use among youth (ages 13-20 years old) in foster care.

    at UCSF

  • Massed Prolonged Exposure for PTSD in Substance Use Treatment

    Sorry, not yet accepting patients

    The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder…

    at UCSD

  • N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use

    Sorry, in progress, not accepting new patients

    Tobacco and cannabis co-use is a common and growing public health problem, especially in states that have legalized cannabis. There are no pharmacologic treatments for co-occurring tobacco and cannabis use. Co-use may make quitting either substance…

    at UCSF

  • THC and CBD: a Controlled Human Study Probing a Harm Reduction Strategy

    Sorry, not yet accepting patients

    The purpose of this research is to assess the impact of CBD on the effects of THC.

    at UCLA

  • Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

    Sorry, not yet accepting patients

    The overarching goal of this proposal is to integrate patient social risk information into an existing electronic health record (EHR)-based clinical decision support (CDS) tool (CDSv1) to facilitate emergency department (ED)-initiated, social…

    at UCSF

  • Latent Structure of Multi-level Assessments and Predictors of Outcomes for Women in Recovery

    Sorry, in progress, not accepting new patients

    In this study the investigators will seek to improve their understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of trauma, mood, substance use, and eating behavior for women…

    at UCSD

Our lead scientists for Substance Abuse research studies include .

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