for people ages 18 years and up (full criteria)
at UC Irvine
study started
completion around
Principal Investigator
by Mahtab Jafari (uci)



This is an observational pilot study to examine the association between a patient's personality and adherence to tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia.

Official Title

Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Patients With Chronic Myeloid Leukemia


The purpose of this pilot study is to explore the association between personality and adherence to a specific type of oral cancer medication - tyrosine kinase inhibitor (TKI) - in patients with chronic myeloid leukemia (CML). 75 individuals with chronic phase CML who are being treated with TKIs will be recruited. Consenting patients will participate in a focused interview where TKI adherence, personality type, and quality of life and symptom burden will be assessed using validated questionnaires. Information on treatment response and the treating physician's perception of TKI adherence will be obtained from the electronic health record.


Chronic Myeloid Leukemia, Chronic Phase Chronic Myelogenous Leukemia, Leukemia, Myeloid Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Chronic-Phase, Interview


You can join if…

Open to people ages 18 years and up

  • 18 years of age or older
  • Diagnosed with chronic myeloid leukemia (CML) and in the chronic phase (CML-CP)
  • Currently being treated with one of four cancer medications - imatinib, dasatinib, bosutinib, or nilotinib
  • A patient at the UCI Chao Family Comprehensive Cancer Center (CFCCC), or
  • A member of a patient support group organized by the CML Buster Foundation
  • Do not meet any of the criteria listed under "Exclusion Requirements"

You CAN'T join if...

  • Unable to read and speak English
  • Impaired decisional capacity to consent


  • Chao Family Comprehensive Cancer Center University of California, Irvine accepting new patients
    Orange California 92868 United States

Lead Scientist at University of California Health

  • Mahtab Jafari (uci)
    Professor, Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences. Authored (or co-authored) 40 research publications


accepting new patients
Start Date
Completion Date
University of California, Irvine
Study Type
Expecting 75 study participants
Last Updated