Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCSF
Dates
study started
completion around

Description

Summary

The purpose of this study is to evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo plus atezolizumab administered to participants with non-small cell lung cancer (NSCLC) following resection and adjuvant chemotherapy.

Official Title

A Phase III, Randomized, Double-blind Study of Tiragolumab Plus Atezolizumab Compared With Placebo Plus Atezolizumab in Participants With Completely Resected Stage IIB, IIIA, or Select IIIB, PD-L1 Positive, Non-small Cell Lung Cancer Who Have Received Adjuvant Platinum-based Chemotherapy

Keywords

Non-small Cell Lung Cancer (NSCLC), Lung Neoplasms, Non-Small-Cell Lung Carcinoma, Atezolizumab, Tiragolumab, Atezolizumab + Tiragolumab

Eligibility

You can join if…

Open to people ages 18 years and up

  • Eastern Cooperative Oncology Group performance status of 0 or 1
  • Histological or cytological diagnosis of Stage IIB, IIIA, and select IIIB NSCLC of either non-squamous or squamous histology
  • Participants must have had complete resection of NSCLC
  • Participants must have received between one to four cycles of adjuvant histology-based platinum doublet chemotherapy
  • Participants must have recovered adequately from surgery and from adjuvant chemotherapy
  • Tumor cell PD-L1 expression at >/= 1%
  • Adequate hematologic and end-organ function.

You CAN'T join if...

  • Any history of prior NSCLC within the last 5 years
  • Any evidence of residual disease or disease recurrence following surgical resection of NSCLC, or during or following adjuvant chemotherapy
  • NSCLC known to have mutation in the EGFR gene or an ALK fusion oncogene

Locations

  • University of California, San Francisco; Medical Center accepting new patients
    San Francisco California 94158 United States
  • The Oncology Institute of Hope and Innovation; Cerritos accepting new patients
    Cerritos California 90703 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Hoffmann-La Roche
ID
NCT06267001
Phase
Phase 3 research study
Study Type
Interventional
Participants
Expecting 1150 study participants
Last Updated