Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created by Two Different Systems

Open to people ages 18 years and up

• Kellgren-Lawrence (KL) Grade 1-3 knee osteoarthritis
• Symptoms of knee osteoarthritis for at least 3 months before presentation in one knee
• Will be able to attend and perform physical therapy

• Received injection therapy for knee osteoarthritis in the past 6 months
• Have severe arthritis diagnosed in ≥1 major joint by radiology criteria
• History of septic arthritis
• Underwent knee surgery for osteoarthritis or osteochondral defects within 1 year before randomization (e.g., autograft or allograft surgery)
• Have had high tibial osteotomy, partial knee replacement, patellar resurfacing, total knee replacement, or have existing surgical hardware in the knee
• Received a platelet-rich plasma injection elsewhere in the body within the past 3 months
• Have a platelet disorder or bleeding disorder
• Have a rheumatologic disease, autoimmune disorder, immunocompromised status, or active history of cancer
• Are taking chemotherapy, require regular prednisone, or require regular anti-inflammatory use
• Are pregnant, breastfeeding, or unwilling to practice birth control during the study
• If both knees have osteoarthritis and the other knee has KL score equal to or greater than 2.
• Have uncontrolled illness, physical disability, or other contraindication to aerobic exercise training