This study is not yet accepting patients

The Effect of High-Intensity Short-Duration Exercise Versus Moderate-Intensity High-Volume Exercise on Glucose Control

a study on Glucose Control

Summary

Eligibility
for people ages 18 years and up (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCSF
Dates
study started
study ends around
Principal Investigator
by Jeanne Noble, MD (ucsf)
Headshot of Jeanne Noble
Jeanne Noble

Description

Summary

This study will be conducted as a prospective, randomized crossover trial evaluating non-diabetic and pre-diabetic adults ($n=12$) continuously monitored with Dexcom G7 continuous glucose monitors over an 11-day period. Participants will complete two distinct exercise protocols in a randomized sequence: five consecutive days of Zone 2 aerobic exercise and a single session of high-intensity interval training (HIIT). Primary outcome metrics will focus on mean glucose levels and time in range (TIR, defined as $\le 120\text{ mg/dL}$) recorded throughout each active exercise block and its associated recovery window. To evaluate the comparative efficacy of the two modalities, paired within-subject differences will be statistically analyzed against pre-specified non-inferiority margins set at $3\text{ mg/dL}$ for mean glucose, as well as a primary $3$-point and secondary $5$-point margin for time in range.

Official Title

The Effect of High-Intensity Short-Duration Exercise Versus Moderate-Intensity High-Volume Exercise on Glucose Control as Measured by Continuous Glucose Monitoring

Keywords

Glucose Control, High-Intensity Interval Training, High Intensity Interval Training, Moderate Intensity aerobic training, Moderate Intensity Exercise, High Intensity Exercise

Eligibility

You can join if…

Open to people ages 18 years and up

Age 18 years or older. Non-diabetic or pre-diabetic status (defined by medical history or standard screening criteria, e.g., HbA1c < 6.5%).

Capable and willing to participate in both Zone 2 aerobic exercise and high-intensity interval training (HIIT) protocols.

Willing to wear a continuous glucose monitor (Dexcom G7) continuously for the 11-day study duration.

Able to provide written informed consent.

You CAN'T join if...

Diagnosis of Type 1 or Type 2 diabetes. Use of glucose-lowering medications, insulin, or other pharmaceuticals that significantly alter glucose metabolism.

Current skin conditions, allergies, or sensitivities to medical-grade adhesives that prevent continuous glucose monitor placement.

Musculoskeletal, cardiovascular, or neurological conditions that contraindicate vigorous exercise or high-intensity interval training.

Pregnant or planning to become pregnant during the study period. Concurrent participation in another clinical trial or interventional exercise study.

Location

  • University of California, San Francisco
    San Francisco California 94143 United States

Lead Scientist at University of California Health

  • Jeanne Noble, MD (ucsf)
    Professor, Emergency Medicine, School of Medicine. Authored (or co-authored) 13 research publications

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
Links
Related Info
ID
NCT07829042
Study Type
Interventional
Participants
Expecting 12 study participants
Last Updated