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Vitiligo clinical trials at University of California Health

5 in progress, 3 open to eligible people

Showing trials for
  • 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2

    open to eligible people ages 18 years and up

    The purpose of this study is to learn about the safety and effects of the study medicine ritlecitinib for the possible treatment of nonsegmental vitiligo. Vitiligo causes white patches on your skin when the cells that give your skin color are destroyed. Nonsegmental means that it can affect both sides of the body such as both knees and both hands. Ritlecitinib has been tested in earlier clinical studies and has a favorable safety profile. At present there are no approved medications taken by mouth to treat nonsegmental vitiligo. This study is seeking participants who: - Are 18 years of age or older. - are confirmed to have nonsegmental vitiligo for at least 3 months. - Are willing to stop all other treatments that they may be taking for vitiligo. In this study participants will be chosen by chance, like drawing names out of a hat to receive 1 of 3 treatments: •Part I where two different amounts of ritlecitinib (50 mg and 100 mg) are taken once daily. It will be compared to placebo. Placebo is a dummy capsule. It doesn't have any medicine used in the study. Participants receiving placebo who have not responded to treatment after 52 weeks will be given 100 milligrams or 50 milligrams of ritlecitinib for the remaining 52 weeks of the study. • In Part II, participants will only receive 100 milligrams of ritlecitinib. About 1000 participants will take part in Part I and around 450 in Part II globally. The study will compare the experiences of people receiving ritlecitinib to those of the people who do not. This will help see if ritlecitinib is safe and effective. People in Part I will be in this study for about 26 months and people in Part II will be in this study for about 14 months. During the study, participants in part I will need to visit the study site at least 17 times. In part II, participants will visit at least 11 times. Participants will undergo various tests and procedures such as: - vitiligo rating, - physical examinations, - hearing tests, - blood tests, - x-ray, - ECG, - photographs of areas with vitiligo. Participants will be asked to complete questionnaires about their vitiligo.

    at UCSD

  • Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V1)

    open to eligible people ages 18 years and up

    This study is being conducted to determine the efficacy and safety of povorcitinib in participants with nonsegmental vitiligo.

    at UC Irvine

  • Longitudinal Observational Study of Patients Undergoing Therapy for IMISC

    open to all eligible people

    TARGET-DERM is a longitudinal, observational study of adult and pediatric patients being managed for Atopic Dermatitis and other Immune-Mediated Inflammatory Skin Conditions (IMISC) in usual clinical practice. TARGET-DERM will create a research registry of patients with IMISC within academic and community real-world practices in order to assess the safety and effectiveness of current and future therapies.

    at UC Irvine UCSD

  • AMG 714 for Vitiligo

    Sorry, in progress, not accepting new patients

    This study is designed to evaluate the efficacy of AMG 714 for the treatment of adult participants with vitiligo.

    at UC Davis UC Irvine

  • Repigmentation of Stable Vitiligo Lesions Using Spray-On Skin™ Cells

    Sorry, in progress, not accepting new patients

    To evaluate repigmentation and quality of life after treatment of stable vitiligo lesions using the RECELL Device.

    at UC Irvine

Our lead scientists for Vitiligo research studies include .

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