Anxiety clinical trials at University of California Health
33 in progress, 17 open to eligible people
Affect Treatment for Depression and Anxiety
open to eligible people ages 18-65
The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core feature of anhedonia) in…
at UCLA
Aging and Reward System Response to Inflammation and Anxiety Study
open to eligible people ages 60-80
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of…
at UCLA
Benzodiazepine Taper with Cognitive Behavioral Therapy in Patients Using Prescription Opioids
open to eligible people ages 18-85
Taking prescription opioids for pain together with benzodiazepines for the treatment of anxiety disorders is not recommended by the U.S. Food and Drug Administration (FDA) because of the elevated risk of serious complications, including fatal…
at UCLA
BLOOM: Boldly Living outdOOrs for Mental Health
open to eligible people ages 9-12
In 2019, the Office of the California Surgeon General launched the ACEs Aware Initiative in collaboration with the California Department of Health Care Services. This ambitious campaign aims to develop a network of care model of healthcare delivery…
at UCSF
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
open to eligible people ages 21-55
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two…
at UCSD
Filipino Family Health Initiative 1.0
open to eligible people ages 8 years and up
The goal of this clinical trial is to test the effectiveness of an online parenting program on Filipino parents living in California. The main aims are to: - Test the effectiveness of the online Incredible Years® model of parent training and its…
at UCSD
Intervention Trial for Healthcare Workers With Anxiety
open to eligible people ages 18 years and up
The purpose of the study is to conduct an initial test of the efficacy of Emotional Resolution (EmRes) therapy to reduce anxiety in healthcare workers. The investigators hypothesize EmRes will reduce levels of anxiety in participants compared to an…
at UCLA
Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
open to eligible people ages 18-65
There are few treatment options available for patients once they have failed standard psychopharmacological therapy for generalized anxiety disorder. Existing brain stimulation methods such as rTMS fail to target deep brain structures associated…
at UCLA
Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women
open to eligible females ages 18 years and up
Trauma exposure, posttraumatic stress disorder (PTSD), and substance use disorder (SUD) present major threats to public health. PTSD and SUD are major correlates of disability, often resulting in severe social and occupational impairment.…
at UCLA
Pramipexole to Enhance Social Connections
open to eligible people ages 18-50
This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression. The study plans to enroll 108 participants total across two sites (University of…
at UCSD
Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy
open to eligible people ages 18-40
The goal is to optimize peer coaching in order to optimize engagement and outcomes in digital therapy. The unmet mental health needs of community college students are staggering and a growing body of research demonstrates that therapy provided…
at UCLA
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
open to eligible females ages 18-65
Perinatal Mood and Anxiety Disorders (PMADs) encompass a range of mental health disorders that occur during pregnancy and up to one year postpartum. Approximately 13% of women experience PMADs. This rate doubles for those with adverse perinatal…
at UCLA
Reward Processing and Exposure Therapy for Social Anxiety Disorder
open to eligible people ages 18-60
The investigators are conducting a clinical trial of therapy for public speaking anxiety. There are many eligibility criteria, but the main ones are that participants need to be socially anxious and have public speaking anxiety. In this clinical…
at UCLA
S.T.A.N.D. Alacrity Center Signature Project
open to eligible people ages 18-40
The purpose of this study is to evaluate clinical decision-making algorithms for (a) triaging to level of care and (b) adapting level of care in a low income, highly diverse sample of community college students at East Los Angeles College (ELAC).…
at UCLA
Social Support and Enhanced Fear Extinction
open to eligible people ages 18-55
University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support …
at UCLA
Social Support and Reduced Fear Acquisition
open to eligible people ages 18-55
University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support …
at UCLA
The Reducing Risk Study
open to eligible people ages 12-18
The present study will test an innovative mobile health adaptation of a behavioral intervention that improves sleep and mental health concerns among adolescents.
at UCSF
MM120 for Generalized Anxiety Disorder (Voyage)
Sorry, not currently recruiting here
A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating MM120 Compared to Placebo in Generalized Anxiety Disorder - Voyage
at UCSF
Oral AFA-281 in Patients with Alcohol Use Disorder
Sorry, not yet accepting patients
This study will evaluate the safety and exploratory efficacy of AFA-281 in patients with Alcohol use disorder on cravings, subjective response to alcohol, pain thresholds, anxiety, depression, and sleep.
at UCLA
Affect Treatment for Depression and Anxiety (TAD Pilot)
Sorry, in progress, not accepting new patients
The goal of this study is to determine whether subjects who do not show expected clinical improvement during the early course of positive affect treatment (PAT) would benefit from switching to an alternative psychosocial treatment (negative affect…
at UCLA
Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression
Sorry, currently not accepting new patients, but might later
The purpose of this study is to examine the feasibility of a protocol in which individuals with comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete Amplification of Positivity for Alcohol Use Disorder…
at UCSD
By Youth, For Youth: Digital Supported Peer Navigation for Addressing Child Mental Health Inequities
Sorry, not yet accepting patients
Black and Latino youth are more likely to experience an unmet mental health or psychosocial need than do their white counterparts. Schools and primary care clinics are ideal hubs to provide mental health, healthcare, social services, and prevention…
at UCLA UCSF
Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Across Time
Sorry, not yet accepting patients
This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric symptoms and diagnoses…
at UCLA
Music Genre Stereotypes to Boost Relaxation in Chronic Pain Patients
Sorry, not yet accepting patients
Social psychological research has demonstrated that internalized stereotypes affect people's attitudes and behaviors. Music-based interventions that rely on stereotypes might have promise for keeping participants engaged in health interventions,…
at UC Irvine
Partners in Caring for Anxious Youth
Sorry, in progress, not accepting new patients
Pediatric onset anxiety disorders (generalized anxiety, social anxiety, separation anxiety) are highly prevalent, and if untreated, are impairing into adolescence and adulthood. In the largest comparative efficacy study remission occurred in about…
at UCLA
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
Sorry, not yet accepting patients
The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty,…
at UCLA
RCT for Latina Mental Health Using Web-Based Apps
Sorry, not yet accepting patients
This study compares a choice-driven, interactive, evidence-informed storytelling web-based app intervention with links to resources and treatment (Tx) recommendations (made by a character via her blog) and Tx locator, to a web-based app with links…
at UCLA
Scientific Information and Beliefs About Psychological Therapy
Sorry, not yet accepting patients
The success of psychological therapy can be impacted by patients' beliefs, such as their belief in their own ability to complete therapy and their belief that therapy will work. The goal of this clinical trial is to learn whether and when scientific …
at UC Irvine
Spatiotemporal Dynamics of the Human Emotion Network
Sorry, accepting new patients by invitation only
The overall goal of this study is to elucidate how emotion network dynamics relate to the behavioral, autonomic, and experiential changes that accompany emotions and to investigate how emotion network dysfunction relates to affective symptoms.…
at UCSF
Transforming Health and Reducing Perinatal Anxiety Through Virtual Engagement
Sorry, currently not accepting new patients, but might later
The goal of this clinical trial is to evaluate whether digital cognitive behavioral therapy (dCBT) can be used to address clinical anxiety in marginalized and low-income pregnant people in California. The main question it aims to answer is: What is…
at UCLA UCSF
Latent Structure of Multi-level Assessments and Predictors of Outcomes for Women in Recovery
Sorry, in progress, not accepting new patients
In this study the investigators will seek to improve their understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of trauma, mood, substance use, and eating behavior for women…
at UCSD
Optimizing Cognitive Remediation
Sorry, in progress, not accepting new patients
Veterans with mental illness face challenges with community reintegration, including achieving vocational success, attaining their educational goals and going back to school, and maintaining a high quality of life. VA Mental Health Residential…
at UCSD
SKY Breath Intervention
Sorry, in progress, not accepting new patients
Depression is highly debilitating and prevalent among adolescents. Adolescent-onset depression is associated with long, severe, and recurrent episodes that are often not responsive to treatment. There is a dire need to develop novel treatments that…
at UCSF
Our lead scientists for Anxiety research studies include Edward F Chang, MD Kevin Bickart, MD/PhD Sean D Young Jessica Bomyea George M. Slavich, PhD Chloe C Boyle, PHD Kate Taylor Yash B. Joshi, MD PhD Lara Ray, MD Lauren Asarnow, PhD Dana Rose Garfin Nooshin Razani, MD MPH Charles Taylor, PhD Virginia Sturm, PhD Laura Jelliffe Pawlowski, PhD.
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