Asthma clinical trials at University of California Health
17 in progress, 6 open to eligible people
Assessing Rocatinlimab in Moderate-to-severe Asthma
open to eligible people ages 18-75
The primary objective of this study is to describe the efficacy of rocatinlimab in reducing asthma exacerbations.
at UC Irvine
Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and Endotyping
open to eligible people ages 18-75
In this study, a new method will be used to evaluate response to 2 approved biologic therapies, and assess how well each patient responds to each asthma treatment. This study will measure the response to these treatments using genomic and biologic…
at UCSD
Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
open to eligible people ages 18-85
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic Obstructive Pulmonary…
at UCSF
Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
open to eligible people ages 18 years and up
This is a single-center study of 80 subjects with asthma including those with obesity and metabolic dysfunction (MD), those with obesity and without metabolic dysfunction, those with severe asthma and mucus plugging and those with severe asthma and…
at UCSF
Mechanistic Insights From Bronchoscopy Airway Samples
open to eligible people ages 18-70
The purpose of this study is to examine the mechanisms of asthma. The investigators are comparing the cells of individuals with and without asthma and looking at the roles various parts of the cell play in the production and secretion of mucus.
at UCSF
Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
open to eligible people ages 0-20
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The…
at UCLA
PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma
Sorry, not currently recruiting here
The purpose of this study is to compare the effect of budesonide/albuterol metered-dose inhaler (BDA MDI) with albuterol sulfate metered-dose inhaler (AS MDI), both administered as needed, on the annualized rate of severe asthma exacerbations in…
at UCSF
Medication Adherence With Telehealthcare Medication Therapy Management
Sorry, in progress, not accepting new patients
Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) is a multi-center, randomized parallel group study targeted to an at-risk population of…
at UCSF
Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness
Sorry, in progress, not accepting new patients
The primary objective of this study is to evaluate if Broncho-Vaxom® given to high risk infants for 10 days, monthly, for two consecutive years can increase time to occurrence of the first episode of wheezing lower respiratory tract illness (WLRI)…
at UCSF
Pulmonary Specialist-Health Coach Consult Model Study
Sorry, in progress, not accepting new patients
The Pulmonary Specialist-Health Coach Consultation (PuSHCon) study examines the implementation of health coach-assisted consultations to improve access to specialist care and implementation of specialist recommendations for patients with COPD,…
at UCSF
Reducing Overuse of Antibiotics with Decision Support
Sorry, not currently recruiting here
Eliminating inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTI) is the central focus of this research. LRTIs (pneumonia, bronchiolitis, and infection-related exacerbations of asthma) account for nearly one-third of…
at UCSF
Simultaneously Implementing Pathways for Improving Asthma, Pneumonia, and Bronchiolitis Care for Hospitalized Children
Sorry, in progress, not accepting new patients
This study's objective is to identify and test pragmatic and sustainable strategies for implementing a multi-condition clinical pathway intervention for children hospitalized with asthma, pneumonia, or bronchiolitis in community hospitals. The…
at UCSF
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
“Join a severe asthma study unlike any other.”
Sorry, in progress, not accepting new patients
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.
at UC Davis UCSD UCSF
Characterization of Adult Subjects for Asthmatic Research Studies
Sorry, currently not accepting new patients, but might later
This study is designed to characterize subjects in terms of the nature and severity of their asthma and in terms of conditions that may alter the clinical expression of asthma. Some features will be obtained in all subjects. These include a medical…
at UCSF
Mechanisms of Exacerbation of Asthma
Sorry, currently not accepting new patients, but might later
The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.
at UCSF
Severe Asthma Research Program
Sorry, in progress, not accepting new patients
The mission of the SARP is to improve the understanding of severe asthma through integrated study of its clinical and biological features and to evaluate their changes over time. The ultimate goal of these efforts is to promote better treatments for …
at UCSF
NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System
Sorry, in progress, not accepting new patients
The study aims to to use new technologies (ML, AI, NLP), to autonomously identify moderate to severe asthma populations within an EHR system, describe differences in treatment patterns across different populations, and determine trial eligibility.…
at UCSD
Our lead scientists for Asthma research studies include Rachel Willard-Grace, MPH Jaime Deville Kelan Tantisira, MD John Fahy, MD, MS Nirav Bhakta, MD, PhD Prescott Woodruff, MD, MPH.
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