Summary

Eligibility
for people ages 0-20 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCLA
Dates
study started
estimated completion

Description

Summary

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.

Official Title

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs

Keywords

Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Hemophilia, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome, Infections, Communicable Diseases, Coronavirus Infections, Urinary Tract Infections, Hemostatic Disorders, Mucocutaneous Lymph Node Syndrome, Blood Coagulation Disorders, Hyperaldosteronism, Disease, Syndrome, Hemorrhage, Attention Deficit Disorder with Hyperactivity, Metformin, Interferons, Ritonavir, Ribavirin, Lopinavir, Oseltamivir, Remdesivir, Azithromycin, Clindamycin, Meropenem, Voriconazole, Ceftazidime, Fosfomycin, Cefepime, Cefdinir, Dexamethasone, Budesonide, Hydrocortisone, Colchicine, Amiodarone, Bosentan, Guanfacine, Labetalol, Nicardipine, Nifedipine, Milrinone, Furosemide, Spironolactone, Dexmedetomidine, Oxycodone, Gabapentin, Nalbuphine, Clobazam, Zolpidem, Risperidone, Amphetamine, Dextroamphetamine, Sertraline, Tranexamic Acid, Aminocaproic Acid, Terbutaline, Sevelamer

Eligibility

You can join if…

Open to people ages 0-20

  1. Participant is < 21 years of age
  2. Parent/ Legal Guardian/ Adult Participant can understand the consent process and is willing to provide informed consent/HIPAA:
  3. (a) Participant is receiving one or more of the study drugs of interest at the time of enrollment or (b) Participant is NOT receiving one or more of the study drugs of interest but is SARS-COV-2 positive within 60 days prior to enrollment

You CAN'T join if...

  1. Participant has a known pregnancy Below exclusion criteria apply only to participants receiving one or more of the study drugs of interest at the time of enrollment,
  2. Has had intermittent dialysis within previous 24 hours
  3. Has had a kidney transplant within previous 30 days
  4. Has had a liver transplant within previous 1 year
  5. Has had a stem cell transplant within previous 1 year
  6. Has had therapeutic hypothermia within previous 24 hours
  7. Has had plasmapheresis within the previous 24 hours
  8. Has a Ventricular Assist Device
  9. Has any condition which would make the participant, in the opinion of the investigator, unsuitable for the study

Locations

  • University of California accepting new patients
    Los Angeles California 90095 United States
  • Phoenix Children's Hospital accepting new patients
    Phoenix Arizona 85016 United States