Diabetes Type 1 clinical trials at University of California Health
38 in progress, 18 open to eligible people
if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes
open to eligible people ages 12-28
The objective of DIAGNODE-3 is to evaluate the efficacy and safety of three intranodal injections of 4 μg of Diamyd compared to placebo, along with oral Vitamin D supplementation, to preserve endogenous beta cell function and influence glycemic…
at UCSD
VX-880 in Participants With Type 1 Diabetes
open to eligible people ages 18-65
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
at UCSF
Acetazolamide in Persons with Type 1 Diabetes
open to eligible people ages 18 years and up
This is a dose finding trial where participants will receive escalating doses of acetazolamide, each for a 2-week dosing period followed by a 2-week washout period. The three doses examined will be open-label 62.5mg twice daily, 125mg twice daily,…
at UCSD
CGM in Kidney Transplant Recipients
“Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”
open to eligible people ages 18 years and up
The investigators want to study the impact CGM (continuous glucose monitoring) has on patients glycemic control as determined by time in range (TIR 70-180 mg/dL) in the Diabetic Kidney Transplant population.
at UC Davis
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
open to eligible people ages 18-70
This is a single site, double-blind, placebo-controlled, crossover trial to quantify the effects of combination adjunctive therapy on glycemic control, ketogenesis during insulinopenia, insulin resistance, and diabetes burden and quality of life.
at UCSD
Device Use Reimagined Through Education And Mentorship
open to eligible people ages 13-17
Diabetes technology, such as insulin pumps and continuous glucose monitoring devices, can help improve glucose control for people with type 1 diabetes (T1D), which keeps them at lower risk for diabetes complications, but many Latinx adolescents, who …
at UC Davis UCSF
Bolus for Meals in a Closed-loop System
open to eligible people ages 13-19
This study aims to evaluate whether the use of an extended bolus will improve glucose control with high-fat high protein meals using a closed-loop system. The new knowledge gained from this study may provide a method to allow for the proper…
at UCSF
FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)
open to eligible people ages 12-35
This is a randomized, parallel group, double-blind Phase 2 study with a 52-week blinded extension evaluating the safety and efficacy of 3 dose levels of frexalimab in comparison with placebo in participants with newly diagnosed T1D on insulin…
at UCSF
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
open to eligible people ages 18-68
This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control. This study involves two…
at UCLA
Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
open to eligible people ages 12-35
A multi-center, placebo-controlled, double blind, 1:1:1 randomized control clinical trial testing two different JAK Inhibitors abrocitnib, ritlecitinib, and placebo in subjects with recent onset Stage 3 Type 1 Diabetes within 100 days of diagnosis.
at UCSF
Supplemental Synchronous and Asynchronous Telehealth to Improve Glycemic Control for Pediatric Patients With Type 1 Diabetes
open to eligible people ages 5-18
This study will test the hypothesis that supplemental synchronous video visits and supplemental asynchronous remote monitoring can each significantly improve glycemic control for pediatric patients with uncontrolled type 1 diabetes over a 6 month…
at UC Davis
Rituximab-pvvr and Abatacept Vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
open to eligible people ages 8-45
The study is a two-arm, multicenter, double-blinded clinical trial testing sequential therapy with rituximab-pvvr followed by abatacept versus rituximab-pvvr alone in new onset T1D. The primary objective is to test whether the C-peptide response to…
at UCSF
MiniMed™ 780G System with DS5 CGM in Children
open to eligible people ages 2-6
The purpose of this study is to evaluate the safety of the MiniMed 780G insulin pump used in combination with the DS5 CGM in type 1 pediatric subjects (2-6 years of age) in a home setting.
at UCSF
Starting Technology in At Risk Type 1 Diabetes Study
open to eligible people ages 18 years and up
Diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D (A1c>8.5%). In order to examine whether …
at UCLA
Commercial or Open Source Closed Loop Impact on Pregnancy Study
open to eligible females ages 18 years and up
The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The main questions this study aims to answer are: - What are the maternal and…
at UCSF
PS230005 Control-IQ 1.5 Post-Approval Study
open to eligible people ages 2-5
This 522 post-market surveillance study is a single-arm, decentralized prospective observational cohort study designed to collect safety data on Control-IQ technology v1.5 in children with type 1 diabetes ages 2 to <6 years old. Participants will…
at UCSD
TrialNet Pathway to Prevention of T1D
open to eligible people ages 2-45
Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM). Genetic and immunologic factors play a key role in…
at UCLA UCSF
Type 1 Diabetes Extension Study
open to eligible people ages 8-35
This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D). This observational study …
at UCSF
Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function
Sorry, in progress, not accepting new patients
Objectives The objective of this clinical trial is to assess whether ladarixin treatment has an effect to preserve β-cell function and delay the progression of T1D in adolescent and adult patients. The safety of ladarixin in the specific clinical…
at UCSD
Automated Insulin for Management of Intrapartum Glycemia
Sorry, not yet accepting patients
The goal of this clinical trial is learn if automated insulin delivery (AID) systems can be used for glucose management during labor/delivery for pregnant people with type 1 diabetes (T1D). The main questions this study aims to answer are - What are …
at UCSF
Closed Loop and Education for Hypoglycemia Awareness Restoration
Sorry, not yet accepting patients
The purpose of the CLEAR study is to determine the effect on counterregulatory responses (CRR) of intervening (by attempting to strictly avoid hypoglycemia) to improve awareness of hypoglycemic symptoms among adults with type 1 diabetes (T1D) who…
at UCSD
Diabetes Autoimmunity Withdrawn In New Onset and In Established Patients
Sorry, in progress, not accepting new patients
The study is a prospective, randomized, 52-week double-blind, placebo-controlled, multicenter trial in subjects with T1D followed by a 2-year safety follow-up.
at UCSD UCSF
GRA in Patients With Type 1
Sorry, in progress, not accepting new patients
This study will examine the effects a Glucagon Receptor Antagonist (GRA), has on Insulin Sensitivity, Cardiovascular risks (CVD), and Ketone body formation in participants with Type 1 diabetes. The participants will complete blood tests, tests to…
at UCSD
Fully Closed Loop At Home (FCL@Home)
Sorry, in progress, not accepting new patients
Protocol Overview/Synopsis This study will be conducted at 3 sites, with each site performing a session with up to 6 participants with a lower HbA1c (<8.0%) in one of 3 age categories (26-60, 18-25, or 14-17 years) followed by a session of up to 6…
at UCSF
Glucagon Rescue of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes Treated With Volagidemab
Sorry, not currently recruiting here
This trial is designed to evaluate the effect of glucagon receptor antagonism by volagidemab (once weekly) on glucose recovery from hypoglycemia after treatment with glucagon in adults with type 1 diabetes. After informed consent, Screening…
at UCSD
Islet Cell Transplant for Type 1 Diabetes
Sorry, in progress, not accepting new patients
City of Hope National Medical Center, located in Duarte, CA, is hosting a clinical study on islet cell transplantation, an experimental procedure being evaluated as a treatment for patients with type 1 diabetes. Islet cell transplantation involves…
at UCLA
Islet Transplantation With Recipient T-Reg Cells or Deceased Donor Vertebral Bone Marrow Therapy
Sorry, not yet accepting patients
The goal of this clinical trial is to learn if patients who have brittle type 1 diabetes receiving an islet transplantation will have better control of their sugars if they also receive one of 2 types of immune cells along with the islet transplant. …
at UCSF
Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes
Sorry, in progress, not accepting new patients
The primary objective is to test the hypothesis that co-transplantation of allogeneic PTG with adult pancreatic islets (derived from same deceased donor) in the IM site in people with Type 1 diabetes with functioning kidney and/or liver transplants…
at UCSF
Personalized Comprehensive Diabetes Support for Children With Newly Diagnosed Type 1 Diabetes
Sorry, accepting new patients by invitation only
The goal of this clinical trial is to learn if access to a diabetes coach improves quality of life (QOL) for families of children with newly diagnosed type 1 diabetes. The main questions it aims to answer are: 1. Determine if there are beneficial…
at UC Davis
Siplizumab in T1DM
Sorry, in progress, not accepting new patients
This is a multicenter, Phase Ib, open-label, siplizumab dose-finding study in individuals aged 8-45 years with a Type 1 diabetes mellitus (T1DM) diagnosis. within 18 months of V0. Participants will be randomized 1:1:1:1 to one of four possible…
at UCSF
STOP-T1D Low-Dose (ATG)
Sorry, in progress, not accepting new patients
A multi-center, placebo-controlled, double blind, 2:1 randomized control clinical trial testing low-dose ATG vs. placebo in subjects with a 2 year 50% risk of progression to stage 3 T1D.
at UCSF
Suppression of Endogenous Glucose Production by Injectable HDV-Insulin Lispro: A Dose Response Study in Human Subjects With Type 1 Diabetes
Sorry, not yet accepting patients
Single-center, double-blind, random-sequence study assessing the HDV dose-response relationship to Endogenous Glucose Production (EGP), Free Fatty Acids (FFA) and Glucose Disposal Rate (GDR) during a euglycemic clamp procedure following overnight…
at UCSD
SYNERGY PLUS: Evaluation of Next Generation Sensors (NGS) and Algorithm in Patients with Type 1 and Type 2 Diabetes
Sorry, not yet accepting patients
The purpose of this study is to find out how well a new continuous glucose monitor works for people with diabetes. This study will test the performance of the study sensor(s) for 7-14 days of wear in patients who are 11-80 years old with type 1 or…
at UCSF
Teplizumab in Pediatric Stage 2 Type 1 Diabetes
Sorry, in progress, not accepting new patients
The purpose of this study is to assess the safety and pharmacokinetics (PK) of teplizumab in participants with Stage 2 type 1 diabetes who are <8 years of age.
at UCSF
Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol
Sorry, in progress, not accepting new patients
The goal of this trial is to gain initial clinical experience regarding the safety and efficacy of treating type I diabetes in people who have received a kidney transplant by transplanting islets into a new transplant site in the stomach…
at UCSF
Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes
Sorry, not yet accepting patients
This is a single-site study using wearable sensor technology (CGM and smartwatch) to better explain low blood sugars in patients living with type 1 diabetes. Up to 20 participants with T1D will wear a continuous glucose monitor (CGM) and a…
at UCSD
HLA Demographics Study in Adults With Type 1 Diabetes
Sorry, not yet accepting patients
This is a study to evaluate the HLA-DRB1*04:01 genotype in adults that have been diagnosed with type 1 diabetes
at UCSF
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
Sorry, in progress, not accepting new patients
The purpose of this non-interventional extension study is to continue to collect long-term safety and other clinical data for an additional 42 months in participants who completed the PROTECT study.
at UCSF
Our lead scientists for Diabetes Type 1 research studies include Steven D. Mittelman, MD, PhD Jeremy Pettus, MD Jenise C Wong, MD, PhD Schafer Boeder, MD Laya Ekhlaspour, MD Stephen Gitelman Peter Stock, MD, PhD Stephanie Crossen, MD, MPH Andrew M Posselt, MD, PhD Estelle M. Everett, MD Nasim Sobhani, MD.
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