GERD clinical trials at University of California Health

6 in progress, 2 open to eligible people

Showing trials for

  • Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

    open to eligible people ages 18-65

    This is a two-site randomized clinical trial aiming to test whether a modified investigational bariatric surgical procedure can improve gastroesophageal reflux disease (GERD) after sleeve gastrectomy.

    at UC Irvine UCSD

  • Mechanism Versus PPI Trial

    open to eligible people ages 18-89

    The goal of this clinical trial is to learn if a mechanism guided strategy that utilizes a multidisciplinary approach to treat adults patients (age 18-89) with chronic throat symptoms who are undergoing clinical evaluation for laryngopharyngeal reflux (LPR) is more effective than the usual care strategy with proton pump inhibitor (PPI) therapy used in gastroenterology for these patients. The main question it aims to answer is: Will a greater proportion of the mechanism guided strategy participants achieve symptom response in comparison to the usual care strategy participants? If there is a comparison group: Researchers will compare the mechanism guided strategy to usual care strategy to see if treatment response differs between the groups. Participants will be be asked to do the following: - participate in an 8-week blinded study phase where they will be randomized to either 1) Mechanism Guided Strategy or 2) Usual Care Strategy - take an oral capsule daily (omeprazole 40mg or placebo) - come to 3 in-person visits at UC San Diego Health for an intervention visit with a study provider - consider incorporating recommended lifestyle modifications - complete weekly surveys

    at UCSD

  • Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair

    Sorry, in progress, not accepting new patients

    This single-blind randomized control study will follow 142 subjects across 7 sites randomized on a 1:1 ratio to compare treatment efficacy and safety between TIF and LNF in GERD patients with hiatal hernia undergoing hernia repair.

    at UC Irvine

  • Outcome Analysis of POEM and Endoluminal Therapies

    Sorry, accepting new patients by invitation only

    Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.

    at UC Davis

  • Sling-Fiber Preservation POEM vs. Conventional POEM for Reducing Post-POEM GERD

    Sorry, not yet accepting patients

    Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.

    at UC Irvine

  • Johns Hopkins Heartburn Center Registry

    Sorry, accepting new patients by invitation only

    A multi-center, multi-year registry of patients with gastroesophageal reflux disease (GERD) undergoing diagnostic evaluation and/or treatment of GERD and associated diseases and complications.

    at UC Irvine

Our lead scientists for GERD research studies include .

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