Heart Failure clinical trials at University of California Health
46 in progress, 24 open to eligible people
Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
open to eligible people ages 18 years and up
The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks like the study…
at UC Irvine
Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
open to eligible people ages 18 years and up
This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a …
at UC Irvine
ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
open to eligible people ages 18 years and up
This is a prospective, multi-center, randomized, sham-controlled, double-blinded (participant and outcomes assessor) clinical trial.
at UC Irvine UCSD UCSF
CCM in HF with Higher Ejection Fraction
open to eligible people ages 18 years and up
The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤60%.
at UC Davis UCSD UCSF
AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study
open to eligible people ages 18 years and up
Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with heart failure and reduced ejection fraction (HFrEF).
at UCSD UCSF
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
open to eligible people ages 21 years and up
Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion despite usual medical therapy. Eligible ADHF…
at UCSF
DORAYA-HF Early Feasibility Study
open to eligible people ages 18 years and up
The study objective is to evaluate the feasibility of the Doraya Catheter and measure clinical performance and safety endpoints, in ADHF patients deemed to have insufficient diuretic response.
at UCSF
Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
open to eligible people ages up to 17 years
This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period. The primary hypothesis is that vericiguat is superior to placebo in…
at UCLA
LEVosimendan to Improve Exercise Limitation in Patients with PH-HFpEF
open to eligible people ages 18-85
This study will evaluate the efficacy of TNX-103 (oral levosimendan) compared with placebo in subjects with PH-HFpEF as measured by the change in 6-Minute Walk Distance (6 MWD; Day 1 to Week 12).
at UCSF
MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation
open to eligible people ages 18 years and up
Cardiac rehabilitation is a medically recommended program for patients with certain heart conditions. It includes exercise training, health education, and counseling. Unfortunately, many patients do not participate in cardiac rehabilitation. Some…
at UCSF
Metformin for Pulmonary Hypertension HFpEF
open to eligible people ages 18 years and up
The main objective of this study is to determine the clinical efficacy of metformin versus placebo and the therapeutic response with regards to functional capacity and hemodynamics in PH-HFpEF.
at UCSF
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
open to eligible people ages 18-80
It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which will, in turn, translate to improved clinical…
at UCSF
Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants
open to all eligible people
Patent Ductus Arteriosus is a developmental condition commonly observed among preterm infants. It is a condition where the opening between the two major blood vessels leading from the heart fail to close after birth. In the womb, the opening (ductus …
at UC Davis
Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects with Non-Ischemic NYHA Class III Heart Failure
open to eligible people ages 18 years and up
This is a Phase 2 adaptive, double-blinded, placebo-controlled, randomized, multi-center trial study to evaluate the safety and efficacy of a single dose of AB-1002, administered via antegrade intracoronary artery infusion, in males and females age…
at UCSD
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
open to eligible people ages 18 years and up
This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study…
at UCSF
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
open to eligible people ages 18 years and up
The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness. The way it does this is by…
at UCLA
Remote Dielectric Sensing (ReDS) Assisted Diuresis in Acute Decompensated Heart Failure
open to eligible people ages 18 years and up
This study evaluates the use of a wearable vest capable of non-invasively measuring lung fluid content in hospitalized patients with heart failure
at UCSF
Heart Failure Precision Medicine Study
open to eligible people ages 21 years and up
The study aims to test the hypothesis that multi-omics studies can identify Heart Failure profiles at risk of adverse outcomes and evaluate a telemonitoring intervention in the optimization of guideline-directed medical therapy.
at UC Davis
EMPOWER Trial - the Carillon Mitral Contour System® in Treating Heart Failure with At Least Mild FMR
open to eligible people ages 18 years and up
The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating heart failure with functional regurgitation (FMR).
at UCLA UCSF
INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
open to eligible people ages 22 years and up
Study Design: This is an international, multicenter, observational, non-interventional, prospective, blinded, single-arm, two-period study, to collect patient utterances that will be retrospectively analyzed to determine the sensitivity and UPNR of…
at UCSD UCSF
Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure
open to eligible people ages 13-39
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and…
at UCSD
HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
open to eligible people ages 30 years and up
HeartShare is a comprehensive study of heart failure, a common and serious medical condition which occurs when the heart is unable to keep up with the demands of the body, resulting in shortness of breath, fluid retention, and fatigue. HeartShare…
at UC Davis
Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future
open to eligible people ages 18-100
Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation…
at UCSF
Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
open to eligible people ages 0-20
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The…
at UCLA
Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16)
Sorry, in progress, not accepting new patients
This is a Phase 2, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of sotatercept versus placebo in adults with Cpc-PH due to HFpEF. The objective of this study is to evaluate the efficacy, safety and…
at UC Irvine UCLA
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS
Sorry, in progress, not accepting new patients
The purpose of the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT) Trial is to confirm the safety and effectiveness of the MitraClip System for the…
at UC Davis
Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Sorry, not currently recruiting here
This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out…
at UC Irvine
Alleviant ALLAY-HF Study
Sorry, accepting new patients by invitation only
Prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in patients with HFpEF/HFmrEF.
at UCSF
Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients
Sorry, in progress, not accepting new patients
This study is a prospective, multi-center, pivotal trial to study the safety and efficacy of the WiSE-CRT System for Cardiac Re-synchronization Therapy.
at UCSD
Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors
Sorry, in progress, not accepting new patients
This phase IIb trial studies how well low-dose carvedilol works in preventing heart failure in cancer survivors exposed to high dose anthracyclines for management of childhood cancer. Patients who received high-dose anthracycline chemotherapy are at …
at UC Davis UCLA
DASH Diet in Heart Failure Outpatients
“Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”
Sorry, in progress, not accepting new patients
The purpose of this study is to refine the classification of the effectiveness of the DASH diet for outpatient heart failure (HF) management, using behavioral, clinical, and laboratory correlative science approaches.
at UC Davis
Early Feasibility Evaluation of the AccuCinch® Ventricular Restoration System in Patients With Heart Failure and Reduced Ejection Fraction
Sorry, in progress, not accepting new patients
This is a non-randomized, prospective, multi-center Early Feasibility Study to evaluate the AccuCinch® Ventricular Restoration System in Patients with Heart Failure and Reduced Ejection Fraction (HFrEF).
at UCSF
Early Feasibility Study - Edwards APTURE Transcatheter Shunt System
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate initial clinical safety, device functionality and effectiveness of the Edwards Transcatheter Atrial Shunt System.
at UCSD UCSF
Food is Medicine for Patients with Heart Failure
Sorry, not currently recruiting here
This study will look at the effects of providing medically tailored meals (MTMs) to people with heart disease for twelve weeks. The primary outcome of the study is the quality of the diet being consumed in week 12 of the study, as determined by the…
at UCSD
Heart Failure Polypill at a Safety Net Hospital
Sorry, in progress, not accepting new patients
A novel four-drug regimen for heart failure with reduced ejection fraction (HFrEF) extends patients' life expectancy by an average of 6 years compared to traditional therapies, in addition to improving quality of life. Unfortunately, uptake of this…
at UCSF
LUX-Dx TRENDS Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System.
Sorry, in progress, not accepting new patients
The primary objective of this study is to collect sensor data from insertable cardiac monitor systems.
at UC Irvine
TRISCEND II Pivotal Trial
“Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”
Sorry, in progress, not accepting new patients
Pivotal trial to evaluate the safety and effectiveness of the Edwards EVOQUE tricuspid valve replacement system
at UC Davis UCSF
PROACTIVE-HF IDE Trial Heart Failure NYHA Class III
Sorry, in progress, not accepting new patients
This is a prospective, open- label, single arm, multicenter clinical trial to evaluate the safety and effectiveness of the Cordella PA Sensor System in NYHA Class III Heart Failure Patients compared to a Performance Goal (PG).
at UCSD UCSF
Reducing Lung CongestIon Symptoms in Advanced Heart Failure
Sorry, in progress, not accepting new patients
The objective of the RELIEVE-HF study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System by improving meaningful clinical outcomes in patients with New York Heart Association (NYHA) functional Class …
at UCLA UCSF
AT-001 in Patients With Diabetic Cardiomyopathy
Sorry, in progress, not accepting new patients
This is a multicenter, randomized, placebo-controlled, 2-part study to evaluate the safety and efficacy of AT-001 in adult patients (N=675) with Diabetic Cardiomyopathy at high risk of progression to overt heart failure.
at UC Irvine UCLA UCSD
Fontan Dapagliflozin Pilot Study
Sorry, accepting new patients by invitation only
The goal of this clinical trial is to study if an investigational study drug called Dapagliflozin could prevent heart failure from getting worse in adults with Fontan circulation. The main questions it aims to answer are: 1. Does Dapagliflozin…
at UCLA
Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
Sorry, in progress, not accepting new patients
The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate AS as compared with OHFT.
at UCLA UCSD UCSF
XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate if Non-Ischemic Heart Preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport hearts for transplantation.
at UCLA UCSD
Access BNP Clinical Enrollment Study
Sorry, not currently recruiting here
The goal of this study is to collect blood from subjects with a suspicion of either new onset or worsened heart failure to be used for testing studies for a new product to aid in the diagnosis of heart failure.
at UC Davis
Cardiovascular Health Study (CHS)
Sorry, in progress, not accepting new patients
To determine the extent to which known risk factors predict coronary heart disease and stroke in the elderly, to assess the precipitants of coronary heart disease and stroke in the elderly, and to identify the predictors of mortality and functional…
at UC Davis
Destination Therapy Post Approval Study
Sorry, in progress, not accepting new patients
Medtronic is sponsoring the HeartWare™ HVAD™ Destination Therapy (DT) Post Approval Study (PAS) to further confirm safety and effectiveness of the HeartWare Ventricular Assist Device System (HVAD System) when used as intended, in "real-world"…
at UCSD UCSF
Our lead scientists for Heart Failure research studies include Liviu Klein Calvin H. Hirsch, MD Richard Cheng Martin Cadeiras, MD Hari Narayan, MD Alexis Beatty, MD, MAS Nancy J. Halnon, MD Jaime Deville Cheryl Anderson, PhD, MPH, MS Gentian Lluri, MD, PhD Priscilla Hsue, MD Richard K. Leuchter, MD Shweta Motiwala Colette DeJong, MD Marc A Simon, MD, MS Nicholas Wettersten, MD.
Last updated: