for people ages 21-55 (full criteria)
Healthy Volunteers
healthy people welcome
study started
estimated completion
Principal Investigator
by Ziva Cooper, PhD (ucla)



The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.

Official Title

Analgesic and Subjective Effects of Terpenes Administered Alone and in Combination With THC: Potential THC- and Opioid-sparing Effects of Myrcene and ß-caryophyllene


The overall aim of this placebo-controlled study is to examine dose-dependent analgesia, intoxication, abuse liability, and pharmacokinetics of ecologically relevant doses of vaporized myrcene and beta-caryophyllene administered alone or with vaporized THC.


Pain Abuse, Drug Cannabis Analgesia THC Terpenes Substance-Related Disorders Caryophyllene Low THC High THC Low Myrcene High Myrcene Low Beta-Caryophyllene High Beta-Caryophyllene Low strength THC Higher strength THC Low strength myrcene High strength myrcene Low strength BCP High strength BCP Low THC + Low myrcene Low THC + High myrcene High THC + Low myrcerne High THC + High myrcene Low THC + Low BCP Low THC + High BCP High THC + Low BCP High THC + High BCP


You can join if…

Open to people ages 21-55

  • Male or non-pregnant female aged 21-55 years
  • Report non-medical use of cannabis 2-6 days per week
  • Not currently seeking treatment for cannabis use
  • Urine test positive for recent cannabis use
  • Have a Body Mass Index from 18.5 - 34kg/m2.
  • Able to perform all study procedures
  • Must be using a contraceptive method (hormonal or barrier methods)

You CAN'T join if...

  • Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or mild CUD
  • Report using other illicit drugs in the prior 4 weeks
  • If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process revealed any significant illness (e.g., hypertension)
  • Current use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
  • Current pain
  • History of respiratory illness or current respiratory illness
  • History of seizure disorder or current seizure disorder
  • Insensitivity to the cold water stimulus of the Cold Pressor Test


  • University of California, Los Angeles accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at University of California Health

  • Ziva Cooper, PhD (ucla)
    Associate Professor-in-Residence, Psychiatry and Biobehavioral Sciences, Medicine. Authored (or co-authored) 69 research publications


accepting new patients
Start Date
Completion Date
University of California, Los Angeles
Phase 1 research study
Study Type
Expecting 45 study participants
Last Updated