Summary

Eligibility
for people ages 50-79 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCLA
Dates
study started
completion around
Principal Investigator
by Denise Aberle, MD (ucla)
Headshot of Denise Aberle
Denise Aberle

Description

Summary

The goal of this project is to improve lung cancer screening in high-risk individuals by identifying biomarkers of preclinical disease and disease risk that are measured in minimally invasive and non-invasive biospecimens. Existing biomarkers for lung cancer diagnosis as well as new biomarkers discovered specifically in this clinical setting will be examined. Biomarkers that identify individuals at highest risk for being diagnosed with lung cancer prior to the appearance of concerning symptoms could increase the utility of lung cancer surveillance and the efficiency of lung cancer chemoprevention clinical trials. Achieving these goals would improve the detection and treatment of early stage and incipient lung cancer, while restricting the risk of these procedures to those individuals who currently exhibit the early molecular warning signs of impending disease.

Official Title

Detection of Early Lung Cancer Among Military Personnel Study 2 (DECAMP-2): Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer

Details

The Detection of Early lung Cancer Among Military Personnel (DECAMP) consortium is a multidisciplinary and translational research program that includes 7 Veterans Administration Hospitals (VAH), the 4 designated Military Treatment Facilities (MTF) and 4 academic hospitals as clinical study sites, several molecular biomarker laboratories, along with Biostatics, Bioinformatics, Pathology and Biorepository cores. The DECAMP Coordinating Center will facilitate rapid selection, design and execution of clinical studies within this multi-institutional consortium. The ACRIN 4704 study will recruit one cohort to achieve the aims of this study: a longitudinal screening cohort.

Keywords

Pulmonary Disease, Lung Neoplasms, Biosamples from airway and blood

Eligibility

Locations

  • Regents of the University of California LA (Los Angeles VA Healthcare System)
    Los Angeles California 90073 United States
  • University of California Los Angeles Medical Center
    Los Angeles California 90095 United States
  • Naval Medical Center San Diego
    San Diego California 92134 United States

Lead Scientist at University of California Health

  • Denise Aberle, MD (ucla)
    Professor, Radiological Sciences, Medicine. Authored (or co-authored) 119 research publications

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Boston University
ID
NCT02504697
Study Type
Observational
Participants
About 665 people participating
Last Updated