Summary

Eligibility
for people ages 15 years and up (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UC Davis
Dates
study started
completion around

Description

Summary

Lipidome and microbiome analysis in subjects with acne on doxycycline. Investigators will look at the skin lipidome, blood lipidome, gut micro biome and skin micro biome.

Investigators will look at the changes between acne subjects and control participants, but also the changes that occur after the use of antibiotics and how this is altered.

Details

We will look at acne subjects, and controls.

We will look at four things

  1. skin lipidome
  2. skin microbiome
  3. gut microbiome
  4. blood lipidome

Investigators will assess this in acne participants before and after doxycycline and compare them to controls.

Keywords

Acne Vulgaris, Doxycycline

Eligibility

You can join if…

Open to people ages 15 years and up

  • Aged 15 and older
  • Subjects/parents/legal guardian is able to read and comprehend study procedure and consent forms.
  • Have already been prescribed Doxycycline by their physician for acne or to be eligible to be prescribed Doxycycline for acne
  • Have acne that is diagnosed by a board certified dermatologist.

You CAN'T join if...

  • Those who have received systemic antibiotics within four weeks of starting the study.
  • Those who have received systemic isotretinoin within six weeks of starting the study.
  • Those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome
  • Those who are pregnant, prisoners or cognitively impaired.
  • Those subjects who are currently using proton pump inhibits (as studies have shown this may impact the gut microbiome) (4)
  • Those who have a BMI greater than >30 kg/m2, as studies have shown a reduction in the variability of intestinal microbes within this population (5).
  • Those who have initiated or changed brand of oral contraceptive pill within 4 weeks of starting the study.
  • Those who have autoimmune disorders as this group has been shown to have an altered microbiome (6)
  • Those who have diabetes (6), immunodeficiencies (7), inflammatory bowel disease (6), hypercholesterolemia, as these groups have been shown to have altered gut microbiomes
  • Those who have taken oral probiotic supplements (8) within 4 weeks of starting the study
  • Given the nature of the instructions that need to be adhered to for accurate collection of samples and this data, non-English speaking individuals will be excluded from this pilot study.
  • Allergies to the tetracycline group of antibiotics
  • Those who do not fit the inclusion criteria

Location

  • UC Davis Dept of Dermatology
    Sacramento California 95816 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
ID
NCT02713607
Phase
Phase 1/2 Acne Research Study
Study Type
Interventional
Participants
About 30 people participating
Last Updated