Osteoarthritis clinical trials at University of California Health
22 in progress, 10 open to eligible people
Biofeedback Retention in Individuals With AKA
open to eligible people ages 18-70
More than two million Americans are currently living with a full or partial limb loss, and an additional 185,000 amputations occur each year. The majority of amputations occur in the lower limbs. There are many potential causes for amputation, but…
at UCSF
Biologic Therapy to Prevent Osteoarthritis After ACL Injury
open to eligible people ages 18-35
Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury. Unfortunately, ACL reconstruction does not prevent risk …
at UCLA
Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis
open to eligible people ages 45-75
The purpose of this study is to investigate the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe osteoarthritis of the knee. BMAC provides a rich source of mesenchymal stem cells (MSCs) and is a …
at UCSD
Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients
open to eligible people ages 18-99
The goal of this clinical trial is to assess the use of a generative artificial intelligence large language model chatbot in improving decision making factors in patients with hip and knee osteoarthritis. The main questions it aims to answer are:…
at UC Davis
Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
open to eligible people ages 18 years and up
To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis
at UCSD
Anti-inflammatory Diet in Osteoarthritis
open to eligible people ages 18 years and up
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether…
at UCSD
Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
open to eligible people ages 40-79
The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. Pain from arthritis is often due to underlying inflammation in the joint. The inflammation is…
at UCLA
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
open to eligible people ages 40-79
An open label, prospective, two-arm, multicenter, randomized controlled trial comparing SakuraBead genicular artery embolization (GAE) with a control (corticosteroid injection).
at UCLA
Patient and Visit Characteristics on Health Outcomes in Knee Osteoarthritis
open to eligible people ages 50 years and up
The goal of this clinical trial is to understand the patient and clinic visit characteristics that affect health outcomes for individuals with knee osteoarthritis (OA) pain using topical diclofenac gel. The main questions it aims to answer are: -…
at UC Davis
Shoulder ID™ Primary Reversed Glenoid Outcomes Clinical Study
open to eligible people ages 18 years and up
The goal of the Shoulder iD™ Primary Reversed Glenoid Outcomes Clinical Study is to collect safety and performance data on the commercially available Shoulder iD™ Primary Reversed Glenoid device. The study will learn about standard device use in…
at UCSF
Pilot rTMS Trial for Knee Arthritis Pain and Depression
Sorry, not yet accepting patients
Osteoarthritis (OA) is a major public health problem, and involvement of the knee is especially disabling. Symptomatic knee OA has an incidence rate between 40 to 1,020 per 100,000 person years1 and is among the most common causes of disability…
at UCLA
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
Sorry, in progress, not accepting new patients
This is a pivotal study to evaluate the efficacy and safety of a single injection of autologous adipose-derived SVF produced using the GID SVF-2 device system for treatment of pain with concomitant improvement in function associated with…
at UC Davis
Amniotic Suspension Allograft in Patients with Osteoarthritis of the Knee
“Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”
Sorry, in progress, not accepting new patients
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
at UC Davis UCLA
EMPHASYS Cup Position in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
Sorry, not yet accepting patients
The purpose of this research is to gather clinical and radiographic (X-ray) information about EMPHASYS™ acetabular shell (also called a hip 'cup') placement in total hip replacement surgery using a non-invasive surgical navigation system called…
at UC Davis
Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial
Sorry, not currently recruiting here
Cooled radiofrequency ablation (cRFA) of the knee geniculate nerves is a promising treatment option for knee osteoarthritis, but has variable efficacy. Fluoroscopy is the typical guidance of choice, but uses bony landmarks to target these nerves…
at UC Davis
Insignia™ Hip Stem Outcomes Study
Sorry, in progress, not accepting new patients
The objective of this study is to evaluate the safety and effectiveness of the Insignia™ Hip Stem for global market access and post-market clinical follow-up up to 10 years postoperative.
at UCSF
Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?
Sorry, not yet accepting patients
This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of…
at UC Davis
Platelet Rich Plasma Injections In Young And Old Human Subjects
Sorry, not yet accepting patients
This is a randomized, double-blind, placebo-controlled phase 2 study with a secondary crossover phase at the end of the initial trial to ensure all subjects receive one PRP injection. The goal is to identify what proteins change in the blood…
at UCSF
Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
Sorry, in progress, not accepting new patients
The goal of this clinical study is to determine if a single injection of 1 or more dose levels of adeno-associated virus (AAV) gene therapy (GNSC-001) is safe and tolerated compared to placebo in participants with painful osteoarthritis (OA) of the…
at UCSD
Zimmer Trabecular Metal Total Ankle PMCF
Sorry, in progress, not accepting new patients
The primary objective of this study is to obtain implant survivorship and clinical outcome data for commercially available Zimmer Trabecular Metal Total Ankle implants used in primary or revision total ankle arthroplasty. The assessment will include …
at UC Davis
Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty with the Smith+Nephew CATALYSTEM™ Primary Hip System
Sorry, accepting new patients by invitation only
A Multi-Center Study in Patients Undergoing Total Hip Arthroplasty with the Smith+Nephew CATALYSTEM™ Primary Hip System. The purpose of the study is to assess safety and performance of the CATALYSTEM™ and to support product approval in global…
at UCSF
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Sorry, in progress, not accepting new patients
The objectives of this study are to obtain survival and outcome data on the Trabecular Metal Reverse Shoulder System when used in primary or revision reverse total shoulder arthroplasty.
at UCSF
Our lead scientists for Osteoarthritis research studies include Helen Lavretsky, MD Siddharth A. Padia, MD Anthony Luke, MD, MPH Zachary C Lum, DO Monica Guma, MD, PhD Richard Souza Kenneth Kalunian, MD Michelle Dossett, MD, PhD Thomas J. Kremen, MD Erik Hansen Daniel Herman, MD.
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