Sleep Apnea clinical trials at University of California Health

27 in progress, 21 open to eligible people

Showing trials for

  • Acetazolamide for Obstructive Sleep Apnea to Improve Heart Health

    open to eligible people ages 18-50

    Obstructive sleep apnea (OSA) is a severe type of snoring causing people to choke in their sleep. It affects millions of Americans, causing many health problems. For example, patients with OSA often feel very sleepy and are at risk of falling asleep …

    at UCSD

  • Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

    open to eligible females ages 18 years and up

    A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy.

    at UCSF

  • Do Endotypes Predict Response and Sequelae in OSA Patients

    open to eligible people ages 21-65

    This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP,…

    at UCSD

  • Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea

    open to eligible people ages 18 years and up

    Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients. This study has investigated the reliability of this technique, demonstrating …

    at UCLA

  • Myofunctional Therapy on OSA

    open to eligible people ages 18-70

    The primary medical therapies for patients with Obstructive Sleep Apnea syndrome (OSA) require the use of medical devices on a nightly basis to help control breathing during sleep, which can be difficult for patients with mild-to-moderate disease.…

    at UCSD

  • Endotype-Targeted Therapy to Rescue OSA Patients Struggling with CPAP Adherence (TOP-CPAP)

    open to eligible people ages 21-65

    More than 10% of the US population have obstructive sleep apnea (OSA). Standard of care is therapy with CPAP (continuous positive airway pressure) which virtually eliminates OSA. However, most patients use CPAP only for part of the night (4-5hours)…

    at UCSD

  • Endotypic Traits and Obstructive Sleep Apnea Surgery

    open to eligible people ages 21 years and up

    This study will examine factors associated with outcomes after soft palate surgery and medications (acetazolamide, eszopiclone) that may treat other potential causes of obstructive sleep apnea (loop gain, arousal threshold).

    at UCLA

  • Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation

    open to eligible people ages 18 years and up

    To evaluate the safety and effectiveness of the Automatic Expiratory Positive Airway Pressure (Auto-EPAP) feature versus manual expiratory positive airway pressure (EPAP) in the Vivo 45 LS Ventilator.

    at UCSD

  • Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

    open to eligible people ages 65-85

    Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. …

    at UCSD

  • Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety

    open to eligible people ages 21-70

    The purpose of this study is to determine the safety and feasibility of the Magnap magnetic device in the treatment of obstructive sleep apnea (OSA).

    at UCSF

  • Managing Opioid Related Sleep Apnea With Acetazolamide

    open to eligible people ages 18 years and up

    Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB). Treatment of SDB often consists of use of a device during sleep that provides continuous positive…

    at UCSD

  • OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

    open to eligible people ages 18 years and up

    Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in…

    at UCSD

  • Patient-centered and Neurocognitive Outcomes with Acetazolamide for Sleep Apnea

    open to eligible people ages 18 years and up

    Obstructive sleep apnea (OSA) is a severe type of snoring causing people to choke in their sleep. It affects millions of Americans, causing many health problems. For example, patients with OSA often feel very sleepy and are at risk of falling asleep …

    at UCSD

  • Apnea and Insomnia Relief for Veterans With Gulf War Illness

    open to eligible people ages 48-80

    The purpose of this study is to determine whether a behavioral sleep treatment improves sleep and other Gulf War Illness (GWI) symptoms in Gulf War Veterans with GWI.

    at UCSF

  • Reaching for Equity in Sleep Apnea Treatment (REST) Study

    open to eligible people ages 18 years and up

    This study will test a brief telephonic health coaching intervention to improve adherence to positive airway pressure therapy for treatment of obstructive sleep apnea.

    at UCSF

  • Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial

    open to eligible females ages 18-40

    In this study, the researchers are trying to learn more about the relationship between Polycystic Ovary Syndrome and Obstructive Sleep Apnea (OSA). Obstructive Sleep Apnea is a sleep-related breathing disorder that involves a decrease or complete…

    at UCSF

  • Sleep for Stroke Management and Recovery Trial

    open to eligible people ages 18 years and up

    The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6…

    at UC Davis UC Irvine UCLA UCSD UCSF

  • Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

    open to eligible people ages 40-79

    Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD) and obstructive…

    at UCSD

  • Time Restricted Eating in Sleep Apnea

    open to eligible people ages 18-70

    Obstructive sleep apnea (OSA) is a highly prevalent disorder that is associated with both cardiovascular and metabolic dysfunction, such as hypertension, increased blood glucose levels and diabetes, obesity, and nonalcoholic fatty liver. While…

    at UCSD

  • Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth

    open to eligible people ages 18-80

    The investigators will establish how well a novel, quick, and painless way of measuring muscle activity from the mouth and throat works for detecting sleep apnea. This technology is called transmembraneous electromyography (tmEMG). Leveraging two…

    at UCSD

  • Direct Referral for Apnea Monitoring

    open to eligible people ages 18 years and up

    The primary objective of this project is to compare a health care delivery model, Direct Referral for Apnea Monitoring (DREAM), with initial in-person (Traditional) clinic appointments for Veterans at risk for obstructive sleep apnea (OSA). A…

    at UCSF

  • Applying Best Clinical Practices to Patients At High Risk of Respiratory Complications

    Sorry, in progress, not accepting new patients

    The purpose of this study is to: 1. Perform a retrospective analysis on data contained in the UCLA Perioperative Data Warehouse on the incidence of respiratory dysfunction in the post-operative care unit (PACU) before and after the introduction of…

    at UCLA

  • Obstructive Sleep Apnea Treatment in Serious Mental Illness

    Sorry, not yet accepting patients

    Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide. A high proportion of adults with schizophrenia and bipolar disorder have sleep disorders, like obstructive…

    at UCSD

  • Distribution of Ventilation, Respiratory Drive and Gas Exchange: Measurements and Monitoring

    Sorry, accepting new patients by invitation only

    Respiratory physiology involves a complex interplay of elements including control of breathing, respiratory drive, pulmonary mechanics, distribution of ventilation and gas exchange. Body position may also play an important role in respiratory…

    at UCSD

  • remedē System Therapy Study

    Sorry, in progress, not accepting new patients

    The purpose of this non-randomized post market study is to collect clinical data on the safety and effectiveness of the remedē System in a real-world setting.

    at UCSF

  • Tissue-specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia

    Sorry, in progress, not accepting new patients

    Obstructive sleep apnea (OSA) is a common condition associated with significant adverse health outcomes. Our overarching hypothesis is that patients with OSA and hypoxia (H-OSA) have greater degrees of insulin resistance in both liver and adipose…

    at UCSF

  • Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea

    Sorry, accepting new patients by invitation only

    Obesity is a common risk factor for the development of obstructive sleep apnea. However, not all subjects with obesity develop obstructive sleep apnea. This study will attempt to determine the mechanistic drivers between obesity and obstructive…

    at UCSD

Our lead scientists for Sleep Apnea research studies include .

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