Brain Injury clinical trials at University of California Health

29 in progress, 13 open to eligible people

Showing trials for

  • Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

    open to eligible people ages 22-80

    Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target…

    at UCSF

  • Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

    open to eligible people ages 18-65

    The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who…

    at UCSD

  • Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

    open to eligible people ages 18-65

    This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active…

    at UCSD

  • GOALS Cognitive Training Delivered to Aging Veterans in Person or Via Telehealth

    open to eligible people ages 65 years and up

    This study will use technology to deliver effective treatment for cognitive problems associated with TBI to Veterans at home, which may result in improved daily functioning and increased access to health care for the growing population of aging…

    at UCSF

  • Hyperbaric Oxygen Brain Injury Treatment Trial

    open to eligible people ages 16-65

    The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the outcome of severe TBI patients in a subsequent…

    at UCSD

  • Brain Oxygen Optimization in Severe TBI, Phase 3

    “We want to hear your opinions about this study! Click the green button below to share.”

    open to eligible people ages 14 years and up

    BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and…

    at UC Davis UCLA UCSF

  • Mild TBI Assessment & Rehabilitation

    open to eligible people ages 18 years and up

    One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with mild TBI and comorbid conditions. When completed, these studies will inform…

    at UCSF

  • Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury

    open to eligible people ages 18-60

    The proposed study tests the feasibility (Phase I) of PATH neurotraining to improve working memory and attention in mTBI patients rapidly and effectively to provide clinical testing of a therapeutic training for the remediation of cognitive…

    at UCSD

  • Short-term And Longer-term Cognitive Impact Of Neurochecks

    open to eligible people ages 55-100

    The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI). In current practice, the neurocritical care community performs frequent…

    at UCSD

  • Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).

    open to eligible people ages 18-65

    The main goal of this clinical trial is to check if the treatment is safe and well-tolerated. Researchers will compare the MR-301 active drug group with the placebo group to evaluate the safety and tolerability of the drug. Other measurements…

    at UC Davis

  • Telerehabilitation Early After CNS Injury

    open to eligible people ages 18 years and up

    The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI). The therapy treatment targets…

    at UCLA

  • NOninVasive Intracranial PrEssure from Transcranial DoppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients

    open to eligible people ages 18 years and up

    This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University. In this study, the investigators will…

    at UC Davis UCSF

  • Screening Emotions in Adolescents at the Hospital for mTBI

    open to eligible people ages 11-17

    The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing significant new or…

    at UC Davis

  • ELI in TBI 24 Hour

    Sorry, not yet accepting patients

    This is a safety phase 2 clinical trial of intravenous infusion of sodium lactate in patients with severe TBI. This study is intended for patients in the acute setting in an intensive care unit at centers that have been selected to participate in…

    at UCLA

  • FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial

    Sorry, not yet accepting patients

    The goal of this clinical trial is to learn about treatment with fresh frozen plasma (FFP) in individuals with moderate to severe traumatic brain injury. The two main question[s]it aims to answer are: - Is the FFP treatment safe? - Does the FFP…

    at UC Davis

  • Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

    Sorry, accepting new patients by invitation only

    The purpose of this study is to determine if experimental drug treatment improves recovery after TBI as compared to a control (placebo) group. Changes in recovery will be measured throughout the study. The study drugs listed below are approved by…

    at UCSF

  • Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

    Sorry, not yet accepting patients

    The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty,…

    at UCLA

  • TBI Rehabilitation and Activation in Veterans

    Sorry, not yet accepting patients

    This trial will evaluate the impact of a multicomponent program (TBI Rehabilitation and Activation in Veterans; TRAIN-Vets) on improving cognitive function over an 8-month trial period in older Veterans with traumatic brain injury (TBI). Older…

    at UCSF

  • Ketogenic Diet for Pediatric Acute Brain Injury

    Sorry, currently not accepting new patients, but might later

    This is a prospective pilot study evaluating the safety and feasibility of implementing the ketogenic diet in children admitted to the pediatric intensive care unit with acute brain injury such as stroke, traumatic brain injury, and intracerebral…

    at UCLA

  • TRACK-TBI Precision Medicine Part 3 - Option II

    Sorry, not yet accepting patients

    The purpose of this study is to determine if experimental drug treatment improves recovery after TBI as compared to a control (placebo) group. Changes in recovery will be measured throughout the study. The study drug listed below is approved by the…

    at UCSF

  • Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: an Efficacy Study

    Sorry, not yet accepting patients

    Trauma is the leading cause of death and disability in children in the United States. The objective of this study is to evaluate the benefits and harms of tranexamic acid (TXA; a drug that stops bleeding) in severely injured children with…

    at UC Davis

  • Ultrasound Stimulation for Patients in a Disorder of Consciousness

    Sorry, not yet accepting patients

    The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a …

    at UCLA

  • Automated Robotic TCD in Traumatic Brain Injury

    Sorry, not currently recruiting here

    This study's objective is to determine the safety, feasibility and efficacy of prolonged automated robotic TCD monitoring in critically ill patients with severe TBI across multiple clinical sites with varying levels of TCD availability and…

    at UC Davis

  • Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation

    Sorry, in progress, not accepting new patients

    The BEAM study is a multicenter, prospective, observational study in children supported on extracorporeal membrane oxygenation (ECMO). The primary goals of this study are to develop and refine a brain injury multimarker panel for accurate neurologic …

    at UCLA

  • Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

    Sorry, not currently recruiting here

    There are no therapeutic agents that have been shown to improve outcomes from severe traumatic brain injury (TBI). Critical barriers to progress in developing treatments for severe TBI are the lack of: 1) monitoring biomarkers for assessing…

    at UCSD

  • DIAGNOSE CTE Research Project-II

    Sorry, accepting new patients by invitation only

    Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports. RHI can result in concussions and asymptomatic non-concussions to confer risk for Alzheimer's disease (AD) and related dementias (ADRD) including…

    at UCSF

  • TRACK-TBI Longitudinal Biomarker Study

    Sorry, accepting new patients by invitation only

    The overarching goal of this study is to improve understanding of the long-range natural history of TBI by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12 months after injury.

    at UCSF

  • Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Phase 2 Option 1

    Sorry, in progress, not accepting new patients

    This study is being conducted to validate early and ultra-early blood-based and novel imaging biomarkers of Diffuse Axonal Injury (DAI), Microvascular Injury (MVI), and neuroinflammation that may serve as predictive and pharmacodynamic biomarkers in …

    at UCSF

  • Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)

    Sorry, accepting new patients by invitation only

    The overarching goal of this study is to improve understanding of the long-range natural history of TBI and post-traumatic epilepsy (PTE) by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12 months after injury.

    at UCSF

Our lead scientists for Brain Injury research studies include .

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