for people ages 18 years and up (full criteria)
study started
completion around



This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), and Duke University Medical Center. In this study, the investigators will primarily use the monitor mode of the Transcranial Doppler (TCD, non-invasive FDA approved device) to record cerebral blood flow velocity (CBFV) signals from the Middle Cerebral Artery and Internal Carotid Artery. TCD data and intracranial pressure (ICP) data will be collected in the following four scenarios. Each recording is up to 60 minutes in length.

Multimodality high-resolution physiological signals will be collected from brain injured patients: traumatic brain injury, subarachnoid and intracerebral hemorrhage, liver failure, and ischemic stroke. This is not a hypothesis-driven study but rather a signal database development project with a goal to collect multimodality brain monitoring data to support development and validation of algorithms that will be useful for future brain monitoring devices. In particular, the collected data will be used to support:

Development and validation of noninvasive intracranial pressure (nICP) algorithms.

Development and validation of continuous monitoring of neurovascular coupling state for brain injury patients

Development and validation of noninvasive approaches of detecting elevated ICP state.

Development and validation of approaches to determine most likely causes of ICP elevation.

Development and validation of approaches to detect acute cerebral hemodynamic response to various neurovascular procedures.


Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure, Ischemic Stroke, Brain Injuries, Traumatic Brain Injuries, Cerebral Hemorrhage, Hemorrhage, Transcranial Doppler


You can join if…

Open to people ages 18 years and up

  1. Male or female subjects 18 years of age and older
  2. Subjects who have an ICP monitoring device that allows for 30 minutes of continuous monitoring

You CAN'T join if...

  1. Unstable medical illness such as recordings might interfere with medical care
  2. Subjects that don't have a viable temporal window to insonate the middle cerebral artery (MCA)
  3. Subjects that have skull fractures that the attending or study investigators believe participation would add clinical risk to the subject
  4. Subjects that had hemicraniectomy and are still without bone flap


  • University of California San Francisco accepting new patients
    San Francisco California 94143 United States
  • Emory University accepting new patients
    Atlanta Georgia 30322 United States
  • Duke University withdrawn
    Durham North Carolina 27710 United States


accepting new patients
Start Date
Completion Date
Emory University
Study Type
Expecting 432 study participants
Last Updated