Delirium clinical trials at University of California Health

3 in progress, 1 open to eligible people

Showing trials for

  • Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

    open to eligible people ages 60 years and up

    This is a pragmatic phase III, randomized, blinded, double placebo-controlled, three-arm trial of elderly patients following cardiac surgery to assess the relationship between nighttime intravenous (IV) and sublingual dexmedetomidine on postoperative delirium and functional outcomes after surgery.

    at UCSF

  • Sleep Harmonization Via Bundled Team-Based Interventions in the ICU

    Sorry, not yet accepting patients

    SHANTI-ICU compares the effectiveness of two evidence-based multicomponent ICU sleep promotion bundles on delirium and patient-reported sleep quality in critically ill adults. Bundle A is a non-pharmacologic strategy. Bundle B includes all components of Bundle A plus pharmacist-led pharmacologic strategies. Sixteen intensive care units across eight hospitals implement one of the two bundles as a unit-level change to routine care, using a concurrent multiple-intervention stepped wedge randomized design. The primary outcome is delirium incidence, measured using the Confusion Assessment Method for the ICU (CAM-ICU) as documented during routine clinical care. Secondary outcomes are delirium duration, ICU length of stay, nightly patient-reported sleep quality, and overall patient-reported ICU sleep quality. Patients receive the assigned bundle as part of routine care. The study operates under an IRB-approved waiver of informed consent and waiver of HIPAA authorization; there is no individual enrollment procedure.

    at UCSD UCSF

  • Delirium in Children Undergoing Stem Cell Transplantation

    Sorry, in progress, not accepting new patients

    Children undergoing stem cell transplants are at risk for delirium, a temporary change in thinking and behavior. This study will define delirium rates, risk factors, and outcomes. Our eventual goal is to reduce delirium in this population.

    at UCSF

Our lead scientists for Delirium research studies include .

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