Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell Lymphoma (ALPHA2)

Open to people ages 18 years and up

• Histologically confirmed diagnosis of relapsed/refractory large B-cell lymphoma at last relapse per WHO 2017
• At least 1 measurable lesion at time of enrollment
• Relapsed or refractory disease after at least 2 lines of chemotherapy
• ECOG performance status 0 or 1
• Absence of donor (product)-specific anti-HLA antibodies (DSA)
• Adequate hematological, renal, and liver function

• Active central nervous system (CNS) involvement by malignancy
• Current thyroid disorder (including hyperthyroidism), except for subjects with hypothyroidism controlled on a stable dose of hormone replacement therapy
• Any other active malignancies that required systemic treatment within 3 years prior to enrollment
• Radiation therapy within 2 weeks prior to ALLO-647
• Prior irradiation to >25% of the bone marrow
• Hypocellular bone marrow for age by institutional standard as determined from a bone marrow biopsy performed at time of screening
• Autologous hematopoietic stem cell transplant (HSCT) within last 6 months (24 weeks)
• Systemic anti-cancer therapy within 2 weeks prior to receiving ALLO-647
• Subjects with active systemic bacterial, fungal, or viral infection requiring systemic treatment (including positive blood cultures within 7 days before starting lymphodepletion)