for people ages 18-90 (full criteria)
study started
completion around



The study is designed as an international, multicenter prospective cohort study. Patients with presumed glioblastoma (GBM) in- or near eloquent areas on diagnostic MRI will be selected by neurosurgeons. Patients will be treated following one of three study arms: 1) a craniotomy where the resection boundaries for motor or language functions will be identified by the "awake" mapping technique (awake craniotomy, AC); 2) a craniotomy where the resection boundaries for motor functions will be identified by "asleep" mapping techniques (MEPs, SSEPs, continuous dynamic mapping); 3) a craniotomy where the resection boundaries will not be identified by any mapping technique ("no mapping group"). All patients will receive follow-up according to standard practice.


Glioblastoma, Anesthetics, Awake mapping under local anesthesia, Asleep mapping under general anesthesia, Resection under general anesthesia without mapping


You can join if…

Open to people ages 18-90

  1. Age ≥18 years and ≤ 90 years
  2. Tumor diagnosed as GBM on MRI as assessed by the neurosurgeon
  3. Tumors situated in or near eloquent areas; motor cortex, sensory cortex, subcortical pyramidal tract, speech areas or visual areas as indicated on MRI (Sawaya Grading II and II)
  4. The tumor is suitable for resection (according to neurosurgeon)
  5. Written informed consent

You CAN'T join if...

  1. Tumors of the cerebellum, brain stem or midline
  2. Multifocal contrast enhancing lesions
  3. Medical reasons precluding MRI (e.g. pacemaker)
  4. Inability to give written informed consent (e.g. because of severe language barrier)
  5. Second primary malignancy within the past 5 years with the exception of adequately treated in situ carcinoma of any organ or basal cell carcinoma of the skin


  • University of California, San Francisco not yet accepting patients
    San Francisco California 94143 United States
  • Massachusetts General Hospital not yet accepting patients
    Boston Massachusetts 02114-2696 United States
  • Erasmus MC accepting new patients
    Rotterdam Zuid-Holland 3015 CE Netherlands
  • Medical Center Haaglanden not yet accepting patients
    The Hague Zuid-Holland 2261 CP Netherlands


accepting new patients at some sites,
but this study is not currently recruiting here
Start Date
Completion Date
Erasmus Medical Center
Study Type
Expecting 453 study participants
Last Updated