for people ages 18 years and up (full criteria)
at UC Davis
study started
estimated completion
Principal Investigator
by Javier E Lopez, MD (ucdavis)



This study is testing a new brief mindfulness practice for people suffering from long COVID-19 symptoms. People suffering from long COVID are particularly vulnerable to negative emotions, as they must also cope with the long-term uncertainty of physical and psychological stress beyond the acute infection. The goal of the study is to measure the ability of a brief mindfulness practice to promote a sense of well-being in people suffering from long COVID.

Official Title

A Study of Positive Emotions With Long COVID (Post-Acute Sequelae of SARS CoV-2 Infection)


This is a pilot randomized waitlist-controlled clinical trial (RCT) testing a new brief self-care intervention for people suffering from post-acute sequelae SARS-CoV-2 infection (PASC). The overarching goal of this study is to establish the feasibility and early efficacy of microdosing mindfulness as a self-care intervention. The purpose of the intervention is to promote a sense of well-being among PASC patients who currently have limited access to other proven self-care modalities.

Our research question is whether our newly developed training can assist PASC patients to self-microdose mindfulness (5-15 seconds activities in everyday life) and improve on perceived metrics of well-being (primary outcome). Our hypothesis is that self-microdosing mindfulness will evoke positive emotions that can improve well-being on patients suffering of PASC-related symptoms beyond 3 months post COVID-19 infection. If effective, an increased frequency of the mindfulness activity will then help buffer negative emotions (e.g., anger, loneliness, etc.) experienced during the pandemic and associated with ongoing stress and/or somatic symptoms.


Post-Acute COVID-19 Syndrome, Mindfulness, COVID-19, Microdosing of mindfulness


You can join if…

Open to people ages 18 years and up

  • Able to participate in online zoom sessions and complete online surveys for 3 months
  • English speakers
  • Had a mild to moderate in severity COVID-19 infection > 3 months ago, feeling unwell, and are still experiencing in the present at least one PASC-related symptoms:
  • Coughing or feeling short of breath
  • Loss of smell or change in taste
  • Recurrent Fever
  • Body aches, headaches, chest pain, or stomach pain
  • Brain fog (feeling like you can't think clearly)
  • Having trouble sleeping
  • Feeling very tired
  • Mood changes

You CAN'T join if...

  • Adults that were admitted to an intensive care unit or placed on a respirator, had invasive heart (heart catheterization) or lung tests (bronchoscopy) performed.
  • Prisoners


  • University of California Davis
    Sacramento California 95817 United States

Lead Scientist at University of California Health

  • Javier E Lopez, MD (ucdavis)
    Associate Professor, Internal Medicine, School of Medicine. Authored (or co-authored) 22 research publications


in progress, not accepting new patients
Start Date
Completion Date
University of California, Davis
Study Type
Expecting 400 study participants
Last Updated