Summary

Eligibility
for females (full criteria)
Location
at UCLA
Dates
study started
completion around
Principal Investigator
by Mina S Sedrak (ucla)

Description

Summary

This phase II trial tests how well fisetin and exercise works in preventing frailty in breast cancer survivors. Fisetin is a natural substance found in strawberries and other foods and is available as a nutritional supplement. Nutritional supplements may be useful in eliminating cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that cause inflammation and damage nearby healthy cells. Giving fisetin may eliminate senescent cells in patients with breast cancer undergoing physical activity.

Official Title

A Phase II Randomized Placebo-Controlled Study of Fisetin and Exercise to Prevent Frailty in Breast Cancer Survivors

Details

Keywords

Anatomic Stage I Breast Cancer American Joint Committee on Cancer (AJCC) V8, Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, Early Stage Breast Carcinoma, Breast Neoplasms, Frailty, Biospecimen Collection, Educational Intervention, Exercise Intervention, Fisetin, Physical Performance Testing, Quality-of-Life Assessment, fisetin, physical activity handout

Eligibility

Locations

Lead Scientist at University of California Health

  • Mina S Sedrak (ucla)
    Associate Professor, Medicine. Authored (or co-authored) 98 research publications. Research interests: Breast Cancer · Geroscience · Cancer & Aging

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Jonsson Comprehensive Cancer Center
ID
NCT06113016
Phase
Phase 2 research study
Study Type
Interventional
Participants
Expecting 164 study participants
Last Updated